Further Information
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
For WB starting dilution is: 1:1000
NFKB1 is a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
- Legembre, P., et al., J. Biol. Chem. 279(45):46742-46747 (2004).
- Imamura, R., et al., J. Biol. Chem. 279(45):46415-46423 (2004).
- Hung, J.H., et al., J. Biol. Chem. 279(45):46384-46392 (2004).
- Binnicker, M.J., et al., Infect. Immun. 72(11):6408-6417 (2004).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Chicken, Mouse
This NFKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-939 amino acids from human NFKB1.
4790
Nuclear factor NF-kappa-B p105 subunit
NFKB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
105 kDa
P19838
21542418
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Immunology,Signal Transduction
P19838
Optimal dilutions for each application to be determined by the researcher.