Further Information
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Tumor necrosis factor, membrane form, N-terminal fragment, NTF, Intracellular domain 1, ICD1, Intracellular domain 2, ICD2, C-domain 1, C-domain 2, Tumor necrosis factor, soluble form, TNF, TNFA, TNFSF2
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
This gene encodes a multifunctional proinflammatory
cytokine that belongs to the tumor necrosis factor (TNF)
superfamily. This cytokine is mainly secreted by macrophages. It
can bind to, and thus functions through its receptors
TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the
regulation of a wide spectrum of biological processes including
cell proliferation, differentiation, apoptosis, lipid metabolism,
and coagulation. This cytokine has been implicated in a variety of
diseases, including autoimmune diseases, insulin resistance, and
cancer. Knockout studies in mice also suggested the neuroprotective
function of this cytokine.
- Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)
- Kwon, H.J., et al. J. Immunol. 185(7):3980-3989(2010)
- Muller, T., et al. Scand. J. Immunol. 72(4):365-371(2010)
- Qin, H., et al. J. Int. Med. Res. 38(3):760-768(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This TNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the C-terminal region of human TNF.
7124
Tumor necrosis factor
TNF
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
P01375
135934
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Immunology,Obesity,Signal Transduction,
P01375
Optimal dilutions for each application to be determined by the researcher.