Further Information
Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B, S100B
For WB starting dilution is: 1:1000
The protein encoded by this gene is a member of the S100
family of proteins containing 2 EF-hand calcium-binding motifs.
S100 proteins are localized in the cytoplasm and/or nucleus of a
wide range of cells, and involved in the regulation of a number of
cellular processes such as cell cycle progression and
differentiation. S100 genes include at least 13 members which are
located as a cluster on chromosome 1q21; however, this gene is
located at 21q22.3. This protein may function in Neurite extension,
proliferation of melanoma cells, stimulation of Ca2+ fluxes,
inhibition of PKC-mediated phosphorylation, astrocytosis and axonal
proliferation, and inhibition of microtubule assembly. Chromosomal
rearrangements and altered expression of this gene have been
implicated in several neurological, neoplastic, and other types of
diseases, including Alzheimer's disease, Down's syndrome, epilepsy,
amyotrophic lateral sclerosis, melanoma, and type I diabetes.
- Sahoo, N., et al. FEBS Lett. 584(18):3896-3900(2010)
- Lin, J., et al. J. Biol. Chem. 285(35):27487-27498(2010)
- van Dieck, J., et al. FEBS Lett. 584(15):3269-3274(2010)
- Egberts, F., et al. Anticancer Res. 30(5):1799-1805(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the Central region of human S100B/S-100.
6285
Protein S100-B
S100B
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
11 kDa
P04271
134138
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Signal Transduction
P04271
Optimal dilutions for each application to be determined by the researcher.