Further Information
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, CAAX farnesyltransferase subunit alpha, FTase-alpha, Ras proteins prenyltransferase subunit alpha, Type I protein geranyl-geranyltransferase subunit alpha, GGTase-I-alpha, FNTA
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence.
FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.
- Wang, T., et al., Science 271(5252):1120-1122 (1996).
- Zhang, F.L., et al., J. Biol. Chem. 269(5):3175-3180 (1994).
- Andres, D.A., et al., Genomics 18(1):105-112 (1993).
- Omer, C.A., et al., Biochemistry 32(19):5167-5176 (1993).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
This FNTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-360 amino acids from the C-terminal region of human FNTA.
2339
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
FNTA
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
P49354
1346694
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cell Cycle,Signal Transduction
P49354
Optimal dilutions for each application to be determined by the researcher.