Further Information
Pantothenate kinase 2, mitochondrial, hPanK2, Pantothenic acid kinase 2, PANK2, C20orf48
For WB starting dilution is: 1:1000
Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
- Neurology 58: 1673-1674, 2002.
- Hum. Molec. Genet. 12: 321-327, 2003.
- Neurology 61: 1423-1426, 2003.
- Neurology 64: 1810-1812, 2005.
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human PANK2.
80025
Pantothenate kinase 2, mitochondrial
PANK2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
63 kDa
Q9BZ23
118572682
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Obesity,Neuroscience,Signal Transduction
Q9BZ23
Optimal dilutions for each application to be determined by the researcher.