ProSci

MCF2L Antibody

Product Code:
 
PSI-60-130
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

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PSI-60-130-400ul400ul£626.00
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Further Information

Additional Names:
Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like protein, MCF2L, KIAA0362
Application Note:
For WB starting dilution is: 1:1000
Background:
Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.
Background References:
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
  • Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)
  • Yang, Q., et al. BMC Med. Genet.SUPPL 1, S12 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MCF2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1075 amino acids from the C-terminal region of human MCF2L.
NCBI Gene ID #:
23263
NCBI Official Name:
Guanine nucleotide exchange factor DBS
NCBI Official Symbol:
MCF2L
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
128 kDa
Protein Accession #:
O15068
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O15068
User NOte:
Optimal dilutions for each application to be determined by the researcher.