ProSci

MLL3 Antibody

Product Code:
 
PSI-61-300
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Antibody staining MLL3 in human testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
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Antibody staining MLL3 in human testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).

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PSI-61-300-200ul200ul£626.00
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Further Information

Additional Names:
Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, 2.1.1.43, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3
Application Note:
For IHC-P starting dilution is: 1:25
Background:
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
Background References:
  • Ruault M.,et al.Gene 284:73-81(2002).
  • Tan Y.C.,et al.Cancer Detect. Prev. 25:454-469(2001).
  • Hillier L.W.,et al.Nature 424:157-164(2003).
  • Nagase T.,et al.DNA Res. 7:143-150(2000).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This MLL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1175 amino acids from the N-terminal region of human MLL3.
NCBI Gene ID #:
58508
NCBI Official Name:
Histone-lysine N-methyltransferase 2C
NCBI Official Symbol:
KMT2C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
541 kDa
Protein Accession #:
Q8NEZ4
Protein GI Number:
221222521
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q8NEZ4
User NOte:
Optimal dilutions for each application to be determined by the researcher.