ProSci

Mouse Map2k5 Antibody

Product Code:
 
PSI-57-517
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in MDA-MB435 cell line lysates (35ug/lane).
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Western blot analysis of Map2k5 using rabbit polyclonal Mouse Map2k5 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Map2k5 gene.
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Western blot analysis in MDA-MB435 cell line lysates (35ug/lane).
Western blot analysis of Map2k5 using rabbit polyclonal Mouse Map2k5 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Map2k5 gene.

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PSI-57-517-400ul400ul£626.00
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Further Information

Additional Names:
Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5, Map2k5, Mek5, Mkk5, Prkmk5
Application Note:
For WB starting dilution is: 1:1000
Background:
Map2k5 acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Background References:
  • Spiering, D., et al. J. Biol. Chem. 284(37):24972-24980(2009)
  • Carter, E.J., et al. J. Cell. Sci. 122 (PT 17), 3104-3112 (2009) :
  • Sohn, S.J., et al. EMBO J. 27(13):1896-1906(2008)
  • Shishido, T., et al. Circ. Res. 102(11):1416-1425(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This Mouse Map2k5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of mouse Map2k5.
NCBI Gene ID #:
23938
NCBI Official Name:
Dual specificity mitogen-activated protein kinase kinase 5
NCBI Official Symbol:
Map2k5
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
Q9WVS7
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q9WVS7
User NOte:
Optimal dilutions for each application to be determined by the researcher.