ProSci

L1CAM Antibody

Product Code:
 
PSI-58-338
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western Blot at 1:8000 dilution + human fetal brain lysate Lysates/proteins at 20 ug per lane.
2 / 2
Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
❮❯

Western Blot at 1:8000 dilution + human fetal brain lysate Lysates/proteins at 20 ug per lane.
Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).

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PSI-58-338-400ul400ul£626.00
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Further Information

Additional Names:
Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5
Application Note:
For WB starting dilution is: 1:1000
Background:
L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Background References:
  • Schafer, M.K., et al. FEBS Lett. 584(21):4475-4480(2010)
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :
  • Schafer, M.K., et al. Cell. Mol. Life Sci. 67(14):2425-2437(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This L1CAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1154-1182 amino acids from the C-terminal region of human L1CAM.
NCBI Gene ID #:
3897
NCBI Official Name:
Neural cell adhesion molecule L1
NCBI Official Symbol:
L1CAM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
P32004
Protein GI Number:
1705571
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P32004
User NOte:
Optimal dilutions for each application to be determined by the researcher.