ProSci

XPO1 Antibody

Product Code:
 
PSI-62-402
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of XPO1 antibody in mouse bladder tissue lysates (35ug/lane)
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Formalin-fixed and paraffin-embedded human brain tissue reacted with XPO1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western blot analysis of XPO1 antibody in mouse bladder tissue lysates (35ug/lane)
Formalin-fixed and paraffin-embedded human brain tissue reacted with XPO1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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PSI-62-402-400ul400ul£626.00
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Further Information

Additional Names:
Exportin-1, Exp1, Chromosome region maintenance 1 protein homolog, XPO1, CRM1
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50
Background:
XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Background References:
  • Shen,A., Neurosurgery 65 (1), 153-159 (2009)
  • Dong,X., Nat. Struct. Mol. Biol. 16 (5), 558-560 (2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This XPO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 817-846 amino acids from the C-terminal region of human XPO1.
NCBI Gene ID #:
7514
NCBI Official Name:
Exportin-1
NCBI Official Symbol:
XPO1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
123 kDa
Protein Accession #:
O14980
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
O14980
User NOte:
Optimal dilutions for each application to be determined by the researcher.