Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
H/ACA ribonucleoprotein complex subunit 4, 5499-, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1, DKC1, NOLA4
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
DKC1 is a member of the H/ACA snoRNPs (small
nucleolar ribonucleoproteins) gene family. snoRNPs are involved in
various aspects of rRNA processing and modification and have been
classified into two families: C/D and H/ACA. The H/ACA snoRNPs also
include the NOLA1, 2 and 3 proteins. The protein encoded by this
gene and the three NOLA proteins localize to the dense fibrillar
components of nucleoli and to coiled (Cajal) bodies in the nucleus.
Both 18S rRNA production and rRNA pseudouridylation are impaired if
any one of the four proteins is depleted. These four H/ACA snoRNP
proteins are also components of the telomerase complex. The protein
encoded by this gene is related to the Saccharomyces cerevisiae
Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in
a tail-to-tail orientation with the palmitoylated erythrocyte
membrane protein gene and is transcribed in a telomere to
centromere direction. Both nucleotide substitutions and single
trinucleotide repeat polymorphisms have been found in this gene.
Mutations in this gene cause X-linked dyskeratosis congenita, a
disease resulting in reticulate skin pigmentation, mucosal
leukoplakia, nail dystrophy, and progressive bone marrow failure in
most cases.
- Rostamiani, K., et al. Blood Cells Mol. Dis. 44 (2), 88 (2010) :
- Grozdanov, P.N., et al. Hum. Mol. Genet. 18(23):4546-4551(2009)
- Ashbridge, B., et al. Biochemistry 48(46):10858-10865(2009)
- Sieron, P., et al. Br. J. Cancer 101(8):1410-1416(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This DKC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human DKC1.
1736
H/ACA ribonucleoprotein complex subunit 4
DKC1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
58 kDa
O60832
This antibody is purified through a protein A column, followed by peptide affinity purification.
O60832
Optimal dilutions for each application to be determined by the researcher.