ProSci

CD117 Recombinant Protein

Product Code:
 
PSI-96-838
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-838-0.1mg0.1mg£657.00
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Further Information

Additional Names:
CD117,SCFR,c-Kit,KIT
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.
Background References:
  • Neumann I., et al., 2010, Pediatr. Blood Cancer 55:464-470.
  • Blume-Jensen P., et al., 1994, J. Biol. Chem. 269:21793-21802.
  • Sun J., et al.,2009, J. Biol. Chem. 284:11039-11047.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human CD117, His Tag at 2 ug/mL (100 uL/well) can bind Biotinylated Mouse SCF with a linear range of 0.8-62 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3815
NCBI Official Name:
Mast/stem cell growth factor receptor Kit
NCBI Official Symbol:
CD117
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
57.1 kDa
Protein Accession #:
P10721-2
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P10721-2

Documents