AdipoGen Life Sciences

MBP146-78

Product Code:
 
SYN-1227
Regulatory Status:
 
RUO
Storage:
 
+4°C
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Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
4-[2-(4-Fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl] pyridine
Appearance:
Solid.
CAS:
188343-77-3
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C21H22FN3/c1-25-12-8-16(9-13-25)20-14-19(15-6-10-23-11-7-15)21(24-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16,24H,8-9,12-13H2,1H3
InChiKey:
RBWNFHXBUDPAIO-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 188343-77-3. Formula: C21H22FN3. MW: 335.4. MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG. MBP146-78 is a potent inhibitor of both soluble and membrane-associated isoforms of native PKG, as well as recombinant enzyme, with an IC50 of <1nm.
Molecular Formula:
C21H22FN3
Molecular Weight:
335.4
Package Type:
Plastic Vial
Product Description:
MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG. MBP146-78 is a potent inhibitor of both soluble and membrane-associated isoforms of native PKG, as well as recombinant enzyme, with an IC50 of <1nm.
Purity:
>95% (HPLC)
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target: A.M. Gurnett, et al.; J. Biol. Chem. 277, 15913 (2002) | Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase: R.G. Donald, et al.; Eukaryot. Cell 1, 317 (2002) | A role for coccidian cGMP-dependent protein kinase in motility and invasion: H.I. Wiersma, et al.; Int. J. Parasitol. 34, 369 (2004) | Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor: C.A. Diaz, et al.; Mol. Biochem. Parasitol. 146, 78 (2006) | Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase: R.G. Donald, et al.; Mol. Biochem. Parasitol. 149, 86 (2006)