Robotnikinin
| Code | Size | Price |
|---|
| AG-CR1-0069-M001 | 1 mg | £350.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2- phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Appearance:
White solid.
CAS:
1132653-79-2
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,(H,27,29)(H,28,31)/b5-2+/t20-,22-/m0/s1
InChiKey:
DRDSZZCLAHXSAE-BQIDRLATSA-N
Long Description:
Chemical. CAS: 1132653-79-2. Formula: C25H27ClN2O4. MW: 454.9. Synthetic. Sonic hedgehog (Shh) signaling modulator. Inhibits the Shh pathway in human cell lines upstream of Smo. Targets the Shh N-terminal protein.
MDL:
MFCD28899414
Molecular Formula:
C25H27ClN2O4
Molecular Weight:
454.9
Package Type:
Vial
Product Description:
Sonic hedgehog (Shh) signaling modulator [1, 2, 3]. Inhibits the Shh pathway in human cell lines upstream of Smo [1, 2, 3]. Targets the Shh N-terminal protein [1, 2, 3].
Purity:
>97% (NMR)
SMILES:
ClC1=CC=C(CNC(=O)C[C@@H]2CC=CCCC(=O)O[C@@H](CNC2=O)C2=CC=CC=C2)C=C1
Solubility Chemicals:
Soluble in DMSO, ethanol or dimethylformamide.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
A small molecule that binds Hedgehog and blocks its signaling in human cells: B.Z. Stanton, et al.; Nat. Chem. Biol. 5, 154 (2009) | Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog: L.F. Peng, et al.; Bioorg. Med. Chem. Lett. 19, 6319 (2009) | Small-molecule modulators of the Sonic Hedgehog signaling pathway: B.Z. Stanton & L.F. Peng; Mol. Biosyst. 6, 44 (2010) (Review)