GANT61

AdipoGen Life Sciences
Product Code: AG-CR1-3561

CodeSizePrice
AG-CR1-3561-M0011 mg£45.00
Quantity:
AG-CR1-3561-M0055 mg£95.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C

Images

1 / 1
Chemical Structure

Chemical Structure

Further Information

Alternate Names/Synonyms:
NSC 136476; 2,2?-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine
Appearance:
White to off-white solid.
CAS:
500579-04-4
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
InChiKey:
KVQOGDQTWWCZFX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 500579-04-4. Formula: C27H35N5. MW: 429.6. Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU. Displays antiproliferative and antitumor activity in vitro and in vivo. Apoptosis inducer.
MDL:
MFCD14635408
Molecular Formula:
C27H35N5
Molecular Weight:
429.6
Package Type:
Vial
Product Description:
Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription [1]. Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU [1]. Displays antiproliferative and antitumor activity in vitro and in vivo [1, 2 , 3, 4, 5]. Apoptosis inducer [1, 2 , 3, 4, 5].
Purity:
>98%
SMILES:
CN(C)C1=CC=CC=C1CN1CCCN(CC2=C(C=CC=C2)N(C)C)C1C1=CC=NC=C1
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007) | Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells: P. Desch, et al.; Oncogene 29, 4885 (2010) | Hedgehog signaling drives cellular survival in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 1092 (2011) | HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. M. Yan, et al.; Oral Oncol. 47, 504 (2011) | Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 5904 (2011)

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