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Cell and gene therapies are at the forefront of medical innovation, transforming how we treat and potentially cure certain diseases that have previously lacked an effective treatment. Robust clinical pipelines and a growing list of FDA-approved therapies brings hope to many patients, placing tremendous pressure on biopharma companies to accelerate development to meet the growing demand. In contrast to traditional biologics (i.e., monoclonal antibodies), the cells themselves are the therapeutic agent. Therefore, clinical success of cell and gene therapies hinges on access to a consistent and high-quality supply of cellular starting material, which are inherently vulnerable to supply chain complications and setbacks. This is further compounded when donors with unique (and potentially rare) attributes are needed. Partnering with an established and reputable supplier like AllCells can bridge the gap and enable the identification of (and collection from) the right donors that can allow companies to move swiftly from therapeutic discovery to commercialization.
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Human Blood Products
AllCells
Natural killer (NK) cells are members of the innate immune system representing 5-20% of the circulating lymphocytes. Classified as group I Innate Lymphocytes (ILCs), they arise from the same lymphoid progenitor cells as T and B cells and play a critical role in immune surveillance and can mount rapid immune responses to a wide variety of pathological challenges.
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Human Blood Products
AllCells
CD34+ stem cells have the capacity for self-renewal, making them a valuable source of hematopoietic stem and progenitor cells for cell therapies. In fact, allogeneic hematopoietic stem cell (HSC) transplantation has been used routinely as a curative treatment for indications in oncology and regenerative medicine. However, challenges with HLA-matching and potential risk of graft vs. host disease (GvHD) has led to a surge in the development of autologous and allogeneic genetically engineered HSC therapies as alternative treatments. As these programs mature, there is a need for GMP-compliant Mobilized Leukopaks — enriched in high-quality CD34+ cells—to support process validation and qualification. AllCells GMP-compliant Mobilized Leukopaks overcome donor and process variability to mitigate risk in downstream applications to accelerate time-to-market.
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Human Blood Products
AllCells
The isolation of specific cell populations from blood products via immunomagnetic cell separation remains an integral operation in any research organization to enrich target cells for immunology and other fields in life sciences. Outsourcing this time-consuming process to an external supplier can streamline your labs workflow and liberate in-house personnel to focus on other priorities. Bulk isolation by a qualified vendor provides all the quality assurances of a commercial product without incurring any capital or operational costs in house. Get high-yield cell products from a single-donor source. Standard and sequential isolations are available.
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Human Blood Products
AllCells
It is advantageous to identify suitable clinical grade, GMP-compliant raw materials and reliable supply partners early in preclinical development to support rapid and seamless clinical translation of a cell and gene therapy (CGT) candidate. There are very few GMP suppliers who can fulfill the regulatory requirements for donor-sourced materials and identifying one can be a lengthy process. Securing these partnerships early and building in time for vendor evaluation, project discussions and design, documentation, and donor screening can help prevent delays downstream.
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Human Blood Products
AllCells
Technical bulletin for HUMAN BONE MARROW ASPIRATE.
Documents
Human Blood Products
AllCells
By leveraging their recruiting expertise, coupled with novel marketing tactics, AllCells industry-leading donor management program recruits and collects from donors with sickle cell trait (SCT), providing a rare resource to bridge the gap for researchers working to treat SCD.
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Human Blood Products
AllCells
Leukopaks are an enriched leukapheresis product collected from the peripheral blood from a single donor consisting of a large number of mononuclear cells (T cells, B cells, NK cells, and monocytes). Leukapheresis collections result in higher purity and significantly higher MNC content compared to from buffy coat collection. Obtaining higher purity and higher quantities of mononuclear cells (MNCs) is important for research and clinical uses such as cell-based assays (proliferation, T cell activation, etc), cell therapy process development, bio-marker discovery and more.
Documents
Human Blood Products
AllCells
Leukopaks, collected from peripheral blood from a single donor, are an enriched source of mononuclear cells (T cells, B cells, NK cells, and monocytes). Leukapheresis collections provide higher purity and quantity of mononuclear cells (MNCs) than buffy coat collection, which is desirable for research and clinical uses such as cell-based assays (proliferation, T cell activation, etc), cell therapy process development, biomarker discovery and more.
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Human Blood Products
AllCells
Monocytes are large agranular leukocytes comprising ~ 5% - 10% of the circulating white blood cells.
Documents
Human Blood Products
AllCells
The highly conserved Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance.
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Cancer
AdipoGen Life Sciences
ProSci offers a comprehensive suite of services for recombinant antibody development, including antigen design and antibody purification and production. Their expert team uses advanced tools and technologies to develop rabbit recombinant antibodies with a defined structure, providing highly consistent and specific antibodies.
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Service
ProSci
ProSci offers Polyclonal Antibody Services in various custom configurations and standard packages, from Antigen Design and Synthesis to Immunisation to Production.
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Service
ProSci
With more than 800 research-grade biosimilar antibodies in ProScis catalogue, these unique tools are available for researchers worldwide. Complimenting ProScis catalogue is a team of custom antibody specialists that provide researchers with expertise in the design, development, purification, and production of antibodies.
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Service
ProSci
Increase viral particles production & enhance viral infection efficiency.
Documents
Cell & Gene Therapy
Oz Biosciences
Enhance, synchronize and accelerate transduction/infection. Production, capture, concentration & storage.
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Virology
Oz Biosciences
NanOZ-LNP Design Platform - CUSTOMIZED WORKFLOW TAILORED FOR YOUR SPECIFIC APPLICATION/NEEDS.
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Service
Oz Biosciences
OZ Biosciences provide 3 mRNA Production Kits: In vitro Transcription Kit, Capping Kit & Poly(A) Tailing Kit.
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RNA
Oz Biosciences
AdipoGen Life Sciences provides next to key standard research antibiotics, rare metabolites/antibiotics with new chemical structures (often only described once in literature and afterwards lost to research) or old already forgotten substances for lead drug research, seeking new “antibiotics” with new mode of actions and new molecular targets. In addition, these substances can be used for in vitro or in vivo studies based on their biological activities or as standard secondary metabolites, important as chemo-taxonomic markers of microbial species.
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Antibiotics
AdipoGen Life Sciences
Biomarker Assays for Preclinical and Diagnostic Research Studies - Metabolic Syndrome Biomarkers, Inflammatory Diseases Biomarkers, Cancer & Autoimmune Diseases Biomarkers
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ELISA
AdipoGen Life Sciences
Documents
Metabolism
AdipoGen Life Sciences
Focus: Crucial Investment in the Future of Health
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Metabolism
AdipoGen Life Sciences
InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. InVivoKines™ are Fc-based fusion proteins using the Knobs-into-Holes (KIH) technology.
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Proteins
AdipoGen Life Sciences
Gelatex is an Estonian company specialising in developing and manufacturing nanofibrous materials. Their HaloSpinTM is a patented novel solution spinning technology that is scalable, standardised, safe, and more economical than current market alternatives. Gelatexs R&D team are experienced in bio-based, biocompatible, and biodegradable nanofibers manufacture.
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Cell Culture
Gelatex Technologies
The use of Gelacell™ nanofiber scaffolds provides a porous and highly interconnected fibrous network that can act as an unparalleled substitute for the native microenvironment, providing a suitable material for cellular compatibility, tissue engineering, drug discoveries, regenerative medicine, and other relevant cell-biological applications.
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Cell Culture
Gelatex Technologies