Chemodex Labels, Stains, Molecular Probes & Small Molecules - Distributed in the UK & Ireland by Caltag Medsystems
Chemodex
Chemodex is a Swiss company manufacturing an attractive product portfolio, including:
- Common and New Fluorescent Probes
- Stains/Labels/Dyes
- Markers & Probes
- Metabolites
- Building Blocks & Small Molecules
Chemodex is an expert in the synthesis of fluorescent substances derived from fluorophores such as coumarin, fluorescein, rhodamine and pyrene. The reagents are used as probes, stains, markers, NIR-labels, pH-sensors, ion indicators, chelators and in other applications (e.g. analytical biochemistry, immunoassays and microscopy) by life science researchers in academia, biotechnology and the diagnostics & pharmaceutical industry.
The collaboration between Chemodex Ltd and AdipoGen Life Sciences allows us to bring the Chemodex product range to our UK & Ireland customers.
See the Products Available:
DAF Compounds
Fluorescent Probes for the Detection of Nitric Oxide
Nitric oxide (NO) is involved in various physiological and pathological processes in the cell and has been implicated in vasodilation, neurotransmission, cytotoxicity, immune response and inflammation. Within cells, nitric oxide synthase (NOS) catalyses the conversion of arginine to citrulline and NO in the presence of molecular oxygen, tetrahydrobiopterin, NADPH and flavin cofactors. Due to the importance of NO, real-time detection and quantification of NO is of great interest. However, the extremely short half-life of NO limits the study of its physiological effect in vivo. Therefore, NO-sensitive fluorescent probes, such as DAF-2 have been designed and used in real-time imaging of NO.
Zinc Probes for the Detection of Zn2+
Zinc (Zn) is the second most abundant transition metal in the body, and it is essential as a catalytic, structural and regulatory ion. Zinc ions are involved in homeostasis, immune responses, oxidative stress, apoptosis and ageing. Zinc has been proposed to function as a conventional neurotransmitter for the presynaptic neuron and as a transmembrane signal to traverse the postsynaptic neuron. Aberrant zinc metabolism is associated with many neurological diseases, including Alzheimer’s disease, Parkinson’s disease and epilepsy. The most suitable technique for in vivo monitoring of zinc has been proven to be fluorescent imaging using fluorescent zinc probes.
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