Interleukin-36α, β and γ (IL-36α, β and γ), members of the interleukin-1 (IL-1) family, are pro-inflammatory cytokines mainly involved in skin inflammatory diseases, but also in the inflammation of lung or gut. Recently, the lab of Prof. Patrick T. Walsh

Inflammasomes are large multimolecular complexes involved in innate immune response and driving cell fate towards cell death, called pyroptosis. Stress granules are aggregates formed during cellular stress with pro-survival role composed of proteins and mRNA molecules. Recently, the lab of

Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance

Asprosin is a fasting-induced hormone that increases plasma glucose levels in the liver. It also stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). In a recent study, the lab of

A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a key NAD+ biosynthetic enzyme in mammals, decline with age in mice

LAG-3 is a coinhibitory immune checkpoint receptor that inhibits T cell response by binding to MHC-II. In a recent study published in Cell, the lab of Prof Lieping Chen (Yale University, US) identifies Fibrinogen-like protein 1 (FGL1), a molecule secreted