Innaxon - Innate Immunity to Life. The Experts for TLR Agonists & Antagonists - Distributed in the UK & Ireland by Caltag Medsystems
Innaxon
Innaxon develops and manufactures defined "Immunoceuticals" of the highest activity and purity for pre-clinical research and development applications for vaccine adjuvants and immuno-therapy. Their unique biological and synthetic Toll-like Receptor (TLR) ligands are well-characterised and effective biological response modifiers of inappropriate or disproportionate immune responses.
The collaboration between Innaxon and AdipoGen Life Sciences allows us to bring the Innaxon product range to our UK & Ireland customers.
See the Products Available:
The TLR4/LPS Experts - Highest Quality
- TLRpure™: Qualified Purity & Activity
- High potency TLR4-specific ligands
- Ultrapure (no detectable protein, RNA & DNA)
- Tested on TLR4 KO murine macrophages
- Standardised aqueous sterile solutions
- Ready-to-use Lipid A and MPLA solution
- No purification or hazardous solubilisation
- BULK available for in vivo studies
- Excellent lot-to-lot reproducibility
- Broadest LPS chemotype and serotype selection
- More than 40 years of experience in LPS purification & characterisation
The ODN Experts
- Endotoxin-free and sterile
- Potent TLR9 ligands
- Tested on TLR9 KO murine macrophages
- BULK available for in vivo studies
- ddWater Endotoxin-free (sterile) included
- Inhibitory ODNs (iODNs) available
- Negative ODN Controls available
Lipodisq™
Lipodisq™ are novel lipid / polymer nanoparticles that have been developed as mimics of naturally-occurring high-density lipoproteins (HDL). Lipodisq™ particles are in the size range of 11 to 40 nm in diameter enabling enhanced penetration and diffusion into membranes. These nanodisc lipid particles are composed of a hydrophilic shell and hydrophobic core in which hydrophobic active agents can be carried and protected.
The size and shape of the chaperone molecule is a critical factor in Lipodisq™ formation and also defines the properties of the particle, i.e. particle size and/or its biodegradability. Internal properties of the phospholipid membrane support the disposition and stabilisation of drug molecule candidates and preserve the native conformation of membrane-bound molecules. The resulting encapsulated actives are rendered water-soluble and optimised for intracellular penetration/delivery via endosomal uptake mechanisms.
Features of Compounds powered by Lipodisq™
- Actives in Lipodisq™ are biosynthetic water-soluble nanodiscs prepared under SOPs using selected optimised lipid compositions for stable, high-loading capacity of encapsulated active ingredients.
- Actives in Lipodisq™ are detergent-free nano-formulations made of styrene-maleic acid copolymer-lipid particles (SMALP).
- Actives in Lipodisq™ retain the biological activity of the active compound with enhanced bioavailability.
- Lipodisq™ solutions show a good safety profile and are suitable for in vitro and in vivo
Special Features of Innaxon Compounds powered by Lipodisq™
- >1011 particles per ml as determined by Dynamic Light Scattering (DLS).
- Tested in cell culture (human macrophage cell line as tested by MTT viability test).
- Formulations are soluble in water, PBS, Tris and other physiological solutions as formulated in a proprietary, thermostable, aqueous lipid nanoparticulate formulation.
- Formulations are certified sterile solutions with a physiological pH range.
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