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NLRP3 activation can occur through both potassium-dependent and potassium-independent mechanisms. Potassium-dependent mechanisms depend on potassium efflux upon MLKL activation, opening of P2X7 channel or exposure to pore-forming toxins. Potassium-independent activation is mediated through metabolic perturbation.
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Inflammation
Abnova Corporation
Full-length mutant huntingtin (mHTT) can be further processed to generate smaller fragments and the amino-terminal HTT exon1 protein fragments are formed by aberrant splicing. Fragments can undergo self-association, oligomerization, and aggregation in the nucleus and cytoplasm, leading to the formation of inclusions that cause numerous pathogenic mechanisms, including synaptic dysregulation, mitochondrial toxicity, energy imbalance, and impaired axonal transport in Huntington’s disease.
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Antibodies
Abnova Corporation
Inhibition of BAK Activation in the Microenvironment. B cell receptor associated kinases (BAKs) are expressed in not only B cells but also other cell types, and regulate the signaling of other surface receptors within the tumor microenvironment (TME). Evidence has suggested that BAK inhibitors could disrupt the crosstalk between malignant B cells and their microenvironment by suppressing the function of BAKs in those non-tumor cells.
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Kinase
Abnova Corporation
While several studies discovered the therapeutic potential of receptor tyrosine kinase (RTK) inhibition, research has recently put a spotlight on novel kinase targets that influence basal cellular process in cancer. Cyclin-dependent kinase (CDK) is one of the new areas that has been focused. As transcription-associated kinases, CDKs represent opportunities for the development of druggable targets for transcriptional-addicted cancers.
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Kinase
Abnova Corporation
Tumor-Associated Antigens of CAR T Cell Therapy
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Antibodies
Abnova Corporation
Immunoglobulin ELISA Kits
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ELISA
Abnova Corporation
Several PD-associated genes interact with pathways regulating mitochondrial homeostasis. The mutations in these genes encoding proteins, like VPS35, PINK1 and LRRK2, lead to mitochondrial dysfunction and further drive the development of neurodegeneration in PD.
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Proteins
Abnova Corporation
Cell culture has become essential to small and large scale monoclonal antibody productions. Abnova uses a specialized protocol for generating cell culture grade antibodies. Compared to classic cell culture, this method allows for multiple harvests, longer run times and higher concentrated supernatant, and provides customers high purified antibodies with minimal to zero contamination.
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Antibodies
Abnova Corporation
Abnova have over 300 camelid single domain antibodies (sdAbs), derived from alpacas or llamas, with great penetrability and affinity to recognize difficult epitopes. The product lines include FluoTag-Q, FluoTag-X2 and FluoTag-X4, featuring different number of sdAb and coupled fluorophore.
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Antibodies
Abnova Corporation
On February 11, 2020, the novel coronavirus which, at the end of 2019, had been identified as causing severe respiratory disease, was officially named 'Coronavirus Disease 2019'. What is Abnova’s action to support the global response to COVID-19? They offer a range of tools to assist researchers in accelerating infectious disease research, and help healthcare workers deal with the high demand for testing.
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COVID-19
Abnova Corporation
A list of Abnova antibodies, proteins and ELISA kits that are specific for Coronaviruses.
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Antibodies
Abnova Corporation
Abnova offers recombinant human monoclonal antibodies raised against various SARS-CoV or SARS-CoV-2 proteins. These antibodies include humanized and fully human monoclonal antibodies which are much less immunogenic than the original mouse antibodies, but have improvement in their activation of the human immune system.
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Antibodies
Abnova Corporation
Abnova offers RNA markers for precise size determination of double-strand or single strand RNA molecules in denaturing acrylamide gels. These RNA markers consist of RNA transcripts with various size ranges, which are useful for estimating the amount of RNA samples based on your research needs.
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RNA
Abnova Corporation
Angiotensin-converting enzyme 2, or ACE2 receptor, is a protein attached to the surface of many cell types. It serves as the entry point for coronavirus, including HCoV-NL63, SARS-CoV, and SARS-CoV-2 to connect and infect a wide range of human cells. Abnova offers a variety of bioreagents targeting ACE2 and other ACE2 related targets.
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Antibodies
Abnova Corporation
COVID-19 Viral Antigen ELISA Kits are sandwich enzyme-linked immunosorbent assay for the quantitative measurement of COVID-19 viral spike antigens or nucleocapsid antigens.
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ELISA
Abnova Corporation
Neutralizing antibodies are able to block the interaction between viruses and host cells, which can potentially stop the infection. Abnova has developed a group of SARS-CoV-2 S monoclonal antibodies, which are neutralizing mouse monoclonal antibodies targeting recombinant SARS-CoV-2 spike protein.
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Antibodies
Abnova Corporation
Best Selling ELISA Kits from Abnova - Infectious Diseases
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ELISA
Abnova Corporation
Abnova ELISA kits to quantify physiologic hormones. Abnova provides a complete collection of metabolic, androgen, reproductive, thyroid, mineral & bone, and stress hormone ELISA kits across multiple mammalian species.
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ELISA
Abnova Corporation
A comprehensive listing of Abnova's Cas9, Cas12, Cas13 nucleases and nickases, accompanied by validated monoclonal, polyclonal, and conjugated antibodies.
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Proteins
Abnova Corporation
Abnova provides end-to-end solutions for miRNA isolation, reverse transcription for cDNA synthesis, quantification, and screening panels.
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miRNA
Abnova Corporation
List of Abnova Infectious Disease ELISA Kits
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ELISA
Abnova Corporation
High Impact publications relating to Elabscience Flow Cytometry and Cell Function products, August 2022.
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Flow Cytometry
Elabscience
Annexin V kits have been used in many publications with high Impact Factor.
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Apoptosis
Elabscience
Antibodies developed as therapeutics have proven to be valuable tools in the fight against devastating diseases from cancer and autoimmune disorders, to infectious and neurodegenerative diseases. Listed are antibody drug analogs available to researchers worldwide, including reagents targeting: Cancer, Neurodegeneration, Autoimmunity, Inflammation, and Pain, and Infectious Diseases (products are RUO).
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Antibodies
ProSci
Some experiments are very sensitive to even small variations in bioactivity. In order to enable these customers to always use exactly the same units and therefore exactly the same activity, we introduced the tct – culture tested grade. The bioassay for our tct – culture tested products always follows the WHO standard, so that the exact activity can be indicated batch-specific.
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Proteins