GeneCopoeia offers genome-edited cell lines that carry diverse hotspot mutations commonly seen in the cancer signaling pathways including EGFR, KRAS and BRAF, in both homozygous and heterozygous genotypes
Designed for microRNA (miRNA) target identification and functional validation of predicted targets, or to study the regulatory effect of miRNA on target genes.
GeneCopoeia, Inc. a U.S.-based functional genomics company founded in 1999, develops cutting-edge products and services for genomics, proteomics, and molecular and cellular biology. With emphasis on innovative R&D and superior product quality, GeneCopoeia serves the needs of biomedical scientists in academic research, and R&D of pharmaceutical and diagnostic products in their pursuit of discoveries and innovations.
Stable Cas9 integration minimizes the need for co-transfection or co-transduction of sgRNAs. Ideal for high-throughput sgRNA applications.
Cas9 functionally validated using the IndelCheck™ T7 endonuclease Endonuclease I assay.
Single clone isolation provides consistent, high-level Cas9 expression in a uniform genetic background.
Compatible with GeneCopoeia Genome-CRISP™ sgRNA clones, sgRNA libraries, and donor clones.
GeneCopoeias OmicsArray™ antigen protein microarrays are engineered for several powerful applications, including autoantibody detection, biomarker profiling, and characterization of protein-molecule interactions. Antigen protein microarrays enable parallel detection of antibodies or other biomarkers present in patient samples for autoimmune diseases including rheumatoid arthritis, muscular dystrophy, systemic lupus erythematosus, and type 1 diabetes as well as pathogen antibodies.
The Single Doman Antibody (sdAb) from camelids, also known as VHH antibodies, provides cutting-edge technology for antibody research. The sdAb lacks light chains and is smaller and more stable than conventional antibodies yet possesses fully functional antigen-binding capability. Due to its size (a mere 15 kDa), a single domain antibody is adept at reaching otherwise inaccessible epitopes. • Smallest functional antibody unit at ~15 kDa • Unique binding capacity to conformational epitopes and active sites • Unique physical properties can lead to increased stability under extreme temerature and pH, as well as
increased solubility • Recombinantly produced for lot-to-lot reporducibility • Adaptable through antibody engineering • Products for Immune Checkpoints and SARS_Cov_2 targets.
ProSci offers an extensive catalog of influenza research reagents for researchers worldwide. Reagents include influenza A detection sets, influenza matched pair antibodies (for influenza A and B), and more antibodies and recombinant proteins for the different strains of influenza viral antigen. • Extensive catalog of antibodies against diverse Influenza A viruses (IAVs) such as H1, H3, H5, H7, N1, N2, N9, etc.
• Antibodies produced in mice, rabbits, and goats against different peptides or recombinant protein with potential for matched pairs
• Diverse applications with corresponding validation data
• Affordable custom services available, including camelid single domain recombinant services
ProSci offers antibodies specific for point mutations in the Spike protein unique to Variants of Concern, including Omicron and Delta. • Target specific point mutations in the Spike protein
• Bridge the knowledge gap between RNA analysis and protein expression
• Build your own toolbox to investigate SARS-CoV-2 gene expression
• Study circulating variants at protein level
• Determine viral protein distribution in tissues
IL-33 is a nuclear-associated cytokine that is normally released by damaged or necrotic cells acting as an “alarmin”, an immediate indicator of tissue stress. IL-33 is a potent inducer of type 2 immune responses in the context of parasite infections and allergic asthma. New studies have also extended the biology of IL-33 with other functions: i) inducing brown and beige adipocyte thermogenesis and promoting insulin secretion by pancreatic islets; ii) facilitating Treg proliferation to suppress autoimmunity and to potentiate neurological recovery; and iii) exerting multiple roles in the brain.
AdipoGen Life Sciences (AdipoGen) is a research company developing proteins, biochemicals, antibodies and ELISA Kits. To promote the advancement of non-animal alternative approaches (3Rs), AdipoGen implemented the antibody phage display technology in-house to develop monoclonal antibodies without the use of animals. Using this technology, AdipoGen was a forerunner in releasing the first recombinant monoclonal antibody for research on the market in 2010: anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1). Since then, our portfolio of fully validated recombinant antibodies made with the phage display technology continues to grow, with a focus on functional antibodies that can block or activate their respective target.
From raw materials to produce rapid tests, to custom peptide synthesis, ElabScience is committed to providing scientists with the tools to perform SARS-CoV-2 research.
The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of MUC1 in mouse tissue
homogenates, cell lysates, cell culture supernates and other biological fluids
iCell® Cardiomyocytes2 are cardiac myocytes derived from human induced pluripotent stem cells (iPSC). These cardiomyocytes, which are an extension of the well-characterized iCell product line, have been optimized for faster recovery from cryopreservation and can be used in a myriad of functional applications.
The recent article by Block et al. in Scientific Reports indicates that iCell Cardiomyocytes2 have enhanced functional and structural benefits following culture on CELLvoâ„¢ Matrix Plus plates for seven days. This application protocol was produced by FUJUFILM Cellular Dynamics, Inc. and details the steps for plating iCell Cardiomyocytes2 on the CELLvoâ„¢ Matrix Plus plates
Immutex™ is a uniform-sized polystyrene latex (PSL) particle available in a variety
of particle sizes and surface chemistries to meet your specific requirements.