ProSci offers antibodies specific for point mutations in the Spike protein unique to Variants of Concern, including Omicron and Delta. • Target specific point mutations in the Spike protein
• Bridge the knowledge gap between RNA analysis and protein expression
• Build your own toolbox to investigate SARS-CoV-2 gene expression
• Study circulating variants at protein level
• Determine viral protein distribution in tissues
IL-33 is a nuclear-associated cytokine that is normally released by damaged or necrotic cells acting as an “alarmin”, an immediate indicator of tissue stress. IL-33 is a potent inducer of type 2 immune responses in the context of parasite infections and allergic asthma. New studies have also extended the biology of IL-33 with other functions: i) inducing brown and beige adipocyte thermogenesis and promoting insulin secretion by pancreatic islets; ii) facilitating Treg proliferation to suppress autoimmunity and to potentiate neurological recovery; and iii) exerting multiple roles in the brain.
AdipoGen Life Sciences (AdipoGen) is a research company developing proteins, biochemicals, antibodies and ELISA Kits. To promote the advancement of non-animal alternative approaches (3Rs), AdipoGen implemented the antibody phage display technology in-house to develop monoclonal antibodies without the use of animals. Using this technology, AdipoGen was a forerunner in releasing the first recombinant monoclonal antibody for research on the market in 2010: anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1). Since then, our portfolio of fully validated recombinant antibodies made with the phage display technology continues to grow, with a focus on functional antibodies that can block or activate their respective target.
From raw materials to produce rapid tests, to custom peptide synthesis, ElabScience is committed to providing scientists with the tools to perform SARS-CoV-2 research.
The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of MUC1 in mouse tissue
homogenates, cell lysates, cell culture supernates and other biological fluids
iCell® Cardiomyocytes2 are cardiac myocytes derived from human induced pluripotent stem cells (iPSC). These cardiomyocytes, which are an extension of the well-characterized iCell product line, have been optimized for faster recovery from cryopreservation and can be used in a myriad of functional applications.
The recent article by Block et al. in Scientific Reports indicates that iCell Cardiomyocytes2 have enhanced functional and structural benefits following culture on CELLvoâ„¢ Matrix Plus plates for seven days. This application protocol was produced by FUJUFILM Cellular Dynamics, Inc. and details the steps for plating iCell Cardiomyocytes2 on the CELLvoâ„¢ Matrix Plus plates
Immutex™ is a uniform-sized polystyrene latex (PSL) particle available in a variety
of particle sizes and surface chemistries to meet your specific requirements.
An extensive range of tools for COVID-19 research from Adipogen Life Sciences. Including Validated SARS-CoV-2 Research Assays, Antibodies, Proteins, Antiviral Compounds, and more.
Collagen is the major building block in all load bearing tissues including tendon, ligament, bone, and cartilage. Mechanical injury to these tissues causes changes in collagen structure which can initiate pathological processes without detectable morphological changes at the macroscale. Using CHPs you can now visualize the mechanical damage to the triple helix.
The skeletal system has a large quantity of collagen, making visualization of skeletal development, disease and turnover with CHPs a perfect use case. Find out more at 3helix.com
Collagen has a unique triple helical structure that is unfolded in tissues during diseases, development, mechanical injury, and decellularization. 3Helix commercializes labeled collagen hybridizing peptide (CHP) that specifically binds to such unfolded collagen chains.
The CELLvoâ„¢ ChondroMatrix is an Extracellular Matrix (ECM) synthesized in vitro by human articular chondrocytes. This product is composed of proteins that were secreted and assembled by human articular chondrocytes during the production of the matrix.
Despite overwhelming evidence demonstrating the important role of the extracellular matrix in regulating cell behavior, traditional cell culture strategies do little to recreate a natural microenvironment.
Presently, standard culture conditions inevitably lead to phenotypic drift, spontaneous differentiation, replicative senescence, and aberrant phenotypes that are unlike those found in the body.
This may lead to experimental artifact in basic research or suboptimal clinical outcomes in translational research. To address this challenge, we focused our efforts on developing in vitro culture substrates that closely mimic natural microenvironments.
Here we describe the development of scale-able, tissue-specific, cell-derived extracellular matrices for cell culture, and their applications in basic and translation research.
Despite overwhelming evidence demonstrating the important role of the extracellular matrix in regulating cell behavior, traditional cell culture strategies do little to recreate a natural microenvironment.
Presently, standard culture conditions inevitably lead to phenotypic drift, spontaneous differentiation, replicative senescence, and aberrant phenotypes that are unlike those found in the body.
This may lead to experimental artifact in basic research or suboptimal clinical outcomes in translational research. To address this challenge, we focused our efforts on developing in vitro culture substrates that closely mimic natural microenvironments.
Here we describe the development of scale-able, tissue-specific, cell-derived extracellular matrices for cell culture, and their applications in basic and translation research.
The innate immune system plays an essential role in the host's first line of defense
against microbial invasion and involves the recognition of pathogen-associated
molecular patterns (PAMPs) or endogenous danger signals through the sensing of
danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs).
Glycobiology is an integrative science, crossing the fields of chemistry, biology, medicine and material science. In the broadest sense, glycobiology is the study of the structure, biosynthesis and biology of glycans (oligosaccharides, carbohydrates), which are present in every living organism