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Type	Category	Supplier

Targeted Antitumor Drugs: Monoclonal Antibodies Description: TargetMol® can provide you with all kinds of monoclonal antibodies, including various immune checkpoint inhibitors and other types of targeted monoclonal antibodies to meet your experimental needs.
Documents	Antibodies	TargetMol	View
Natural Product Library A broad and diverse herbal source is an important guarantee for a high-quality Natural Product Library. TargetMol has collected massive relevant information of nearly 10,000 natural product monomers and numerous plants in 196 families, 887 genera. We can be a great help for you to search your desired compounds according to plant classifications.
Documents	Small Molecules	TargetMol	View
Compound Libraries List of compound libraries available with TargetMol
Documents	Small Molecules	TargetMol	View
Hot Inhibitors See the most popular inhibitors by TargetMol on the following areas: - mTOr signalling - Angiogenesis - Proteases - MAPK - Stem cells - Ubiquitination - Cell cycle/checkpoint - DNA damage/repair - Microbiology and virology - Apoptosis - NK-Kb - GPCR/G Protein
Documents	Small Molecules	TargetMol	View
Computer-Aided Drug Design
Documents		TargetMol	View
About TargetMol Most popular inhibitors by TargetMol: - PI3K/Akt/mTOR signaling - Angiogenesis - Proteases/Proteasome - MAPK - Stem Cells - Ubiquitination - Cell Cycle/Checkpoint - DNA Damage/DNA Repair - Microbiology and Virology - Apoptosis - NF-kb - GPCR/G Protein
Documents	Small Molecules	TargetMol	View
Drug Repurposing Drug repurposing, also known as the new use of old drugs, is a strategic approach to discover new applications for old or investigational drugs beyond their original approved applications. While the development of new drugs is a process with a high failure rate, high cost, and slow pace, repositioning old drugs for common and rare diseases is becoming increasingly attractive because of the advantages of low R&D costs and short development time.
Documents	Small Molecules	TargetMol	View
Cell Counting Kit-8 (CCK-8) Cell Counting Kit-8 allows convenient assays using WST-8, which produces a water-soluble formazan dye upon reduction in the presence of an electron carrier, 1-Methoxy PMS.
Documents	Cell Based Assays	TargetMol	View
Human Mononuclear Cells for Clinical and Research Applications - Cell Generation Primary PBMCs from Cell Generation are isolated directly from peripheral blood of eligible donors via leukapheresis procedure. Leukapheresis performed following Institutional Review Board (IRB) consented healthy or diseased human donors.
Documents	Biological Samples	Cell Generation	View
Cancer-Associated IDH1/2 Mutations from Abnova IDH1/2 Mutations
Documents	Cancer	Abnova Corporation	View
AR-V7 and Prostate Cancer from Abnova Androgen receptor (AR) is a member of the steroid receptor transcription factor family. In prostate cancer, increased levels of androgens in the tumor cells promote (1) AR signaling associated with cell-cycle regulation, growth, and survival, and (2) the expression of oncogenic fusion genes. AR-V7 is one of the splice variants of AR lacking the C-terminal LBD, but being constitutively active as a transcription factor and capable of promoting activation of target genes.
Documents	Cancer	Abnova Corporation	View
HSF1 Activation Cycle Inactive monomeric heat shock factor 1 (HSF1) exists predominantly in the cytoplasm and remains repressed by complex with regulatory proteins of HSF1 its own transcriptional targets of heat-shock protein (HSP) and cytosolic chaperonin TCP1 ring complex (TRiC). Upon a wide range of stress conditions, HSF1 is activated to undergo trimerization, nuclear translocation, and post-translational modifications (PTMs) including phosphorylation, acetylation, and sumoylation, converted into a DNA-binding-competent, active homotrimer. HSF1 is then modified by different inhibitory PTMs to cause DNA dissociation, HSF1 inactivation, and HSF1 recycling/degradation and maintained in a negative-feedback mechanism.
Documents	Antibodies	Abnova Corporation	View
Flow Cytometry/Cell Function Products_Elabscience_October 2022 High IF Literature in October, 2022
Documents	Flow Cytometry	Elabscience	View
Flow Cytometry/Cell Function Products_Elabscience_November 2022 High IF Literature in November, 2022.
Documents	Flow Cytometry	Elabscience	View
Complement System ELISA Kits from Abnova Complement System ELISA Kits - Complement Components, Complement Regulators, Complement Receptors and Complement Lectin Pathway Targets from Abnova.
Documents	ELISA	Abnova Corporation	View
Popular ELISA & Assay Kits from Abnova Popular ELISA & Assay Kits
Documents	Kits	Abnova Corporation	View
Microglia Function Transition Microglia Function Transition.
Documents	Antibodies	Abnova Corporation	View
NLRP3 Inflammasome in Neurological Diseases from Abnova NLRP3 activation can occur through both potassium-dependent and potassium-independent mechanisms. Potassium-dependent mechanisms depend on potassium efflux upon MLKL activation, opening of P2X7 channel or exposure to pore-forming toxins. Potassium-independent activation is mediated through metabolic perturbation.
Documents	Inflammation	Abnova Corporation	View
Pathogenic Mechanism in Huntington's Disease Full-length mutant huntingtin (mHTT) can be further processed to generate smaller fragments and the amino-terminal HTT exon1 protein fragments are formed by aberrant splicing. Fragments can undergo self-association, oligomerization, and aggregation in the nucleus and cytoplasm, leading to the formation of inclusions that cause numerous pathogenic mechanisms, including synaptic dysregulation, mitochondrial toxicity, energy imbalance, and impaired axonal transport in Huntington’s disease.
Documents	Antibodies	Abnova Corporation	View
B Cell Receptor Associated Kinases in Lymphoma from Abnova Inhibition of BAK Activation in the Microenvironment. B cell receptor associated kinases (BAKs) are expressed in not only B cells but also other cell types, and regulate the signaling of other surface receptors within the tumor microenvironment (TME). Evidence has suggested that BAK inhibitors could disrupt the crosstalk between malignant B cells and their microenvironment by suppressing the function of BAKs in those non-tumor cells.
Documents	Kinase	Abnova Corporation	View
Transcriptional Cyclin-Dependent Kinase in Cancer from Abnova While several studies discovered the therapeutic potential of receptor tyrosine kinase (RTK) inhibition, research has recently put a spotlight on novel kinase targets that influence basal cellular process in cancer. Cyclin-dependent kinase (CDK) is one of the new areas that has been focused. As transcription-associated kinases, CDKs represent opportunities for the development of druggable targets for transcriptional-addicted cancers.
Documents	Kinase	Abnova Corporation	View
Tumor-Associated Antigens of CAR T Cell Therapy from Abnova Tumor-Associated Antigens of CAR T Cell Therapy
Documents	Antibodies	Abnova Corporation	View
Immunoglobulin ELISA Kits from Abnova Immunoglobulin ELISA Kits
Documents	ELISA	Abnova Corporation	View
Parkinson's Disease-associated Proteins in Mitochondrial Homeostasis Several PD-associated genes interact with pathways regulating mitochondrial homeostasis. The mutations in these genes encoding proteins, like VPS35, PINK1 and LRRK2, lead to mitochondrial dysfunction and further drive the development of neurodegeneration in PD.
Documents	Proteins	Abnova Corporation	View
Cell Culture Grade Antibodies Cell culture has become essential to small and large scale monoclonal antibody productions. Abnova uses a specialized protocol for generating cell culture grade antibodies. Compared to classic cell culture, this method allows for multiple harvests, longer run times and higher concentrated supernatant, and provides customers high purified antibodies with minimal to zero contamination.
Documents	Antibodies	Abnova Corporation	View

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