HER2, EGFR, HER3, and IGF-1R dimerized with the HER2 receptor induce activation of PI3K/AKT and MAPK/MEK signalling pathways and receive signals to regulate the downstream cascade that promotes the active transcription of genes involved in proliferation, angiogenesis, cell survival, and metastasis.
The ELISpot Assay is a versatile and highly sensitive method for ex-vivo analysis of protein secretion post cell stimulation. Virtue of its high sensitivity (1 cell in 100,000) the ELISpot assay enables frequency analysis of activated cell populations or antigen-specific cell responses at the single cell level and therefore can measure the magnitude of specific T-cell immunity.
Silensomes™ are validated human pooled liver microsomes (HLMs) chemically and irreversibly inactivated for one specific CYP450 using mechanism based inhibitors (MBI).
Biopredics HSCs have cell quality post-thawing, specific marker expression post-thawing/plating and are quiescent 6 days after culture in a reversion medium.
Nordic-MUbio is pleased to announce the release of one of the original antibodies (MUB2058) developed for the identification and characterisation of Thy-1 (CD90) in rats, used in some of the highly cited work of Barclay et al.
ABT offers a wide range of non-activated agarose resins for Size Exclusion and activation procedures, as well as activated agarose beads for Affinity Chromatography, Ion Exchange Chromatography, and Pre-activated resins for coupling of affinity ligands (immobilisation).
Integration is the solution to deciphering the complexity of biology. The core of Abnovas integration is the generation and availability of antibodies and proteins targeting the human genome. These invaluable bio-tools are combined and utilised in a comprehensive repertoire of qualitative, quantitative, multiplexing, high throughput, and profiling applications to address the needs of research and discovery. Abnova has successfully developed and implemented these integrated solutions for the research community and industry.
The highly conserved Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance.
ProSci offers a comprehensive suite of services for recombinant antibody development, including antigen design and antibody purification and production. Their expert team uses advanced tools and technologies to develop rabbit recombinant antibodies with a defined structure, providing highly consistent and specific antibodies.
ProSci offers Polyclonal Antibody Services in various custom configurations and standard packages, from Antigen Design and Synthesis to Immunisation to Production.