GFRAL (human):Fc (human) (rec.)
| Code | Size | Price |
|---|
| CHI-HF-210GFRAL-C100 | 100 ug | £465.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
BI
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
GDNF Family Receptor alpha-like; Gral; Glial Cellline-derived Neurotrophic Factor Receptor alpha-like; GFR alpha-like; C6orf144
Biological Activity:
Measured by its binding ability in a functional ELISA.
EClass:
32160000
Endotoxin:
<1EU/mg purified protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Recombinant protein. The extracellular domain of human GFRAL (aa 19-351) is fused to the N-terminus of the Fc region of human IgG1. Measured by its binding ability in a functional ELISA. Source/Host: HEK 293 cells. Purity: >98% (SDS-PAGE). Lyophilized from 0.2µm-filtered solution in PBS. GFRAL (GDNF receptor alpha-like) is a distant member of the GDNFR family of proteins. Human GFR alpha-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.
Molecular Weight:
~50-100kDa
NCBI, Uniprot Number:
NP_997293.2
Package Type:
Plastic Vial
Product Description:
GFRAL (GDNF receptor alpha-like) is a distant member of the GDNFR family of proteins. Human GFR alpha-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.
Purity:
>98% (SDS-PAGE)
Sequence:
The extracellular domain of human GFRAL (aa 19-351) is fused to the N-terminus of the Fc region of human IgG1.
Source / Host:
HEK 293 cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Interleukins
UNSPSC Number:
41116127
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.