Cycloastragenol
| Code | Size | Price |
|---|
| CDX-C0592-M050 | 50 mg | £84.00 |
Quantity:
| CDX-C0592-M100 | 100 mg | £126.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Astramembrangenin; Cyclogalegigenin; Cyclosieversigenin; Cyclosiversigenin; GRN510; TAT2
Appearance:
White to off-white powder.
CAS:
84605-18-5
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1
InChiKey:
WENNXORDXYGDTP-UOUCMYEWSA-N
Long Description:
Chemical. CAS: 84605-18-5. Formula: C30H50O5. MW: 490.73. Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species. Extensive pharmacological effects have been attributed to cycloastragenol, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties, improvement of lipid metabolism and wound repair promotion. It has been shown to inhibit endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and NLRP3 inflammasome-mediated pyroptosis. It improved immune function in CD8+ T lymphocytes from HIV-1-infected patients. It might be a novel candidate for age-associated diseases.
MDL:
MFCD24849201
Molecular Formula:
C30H50O5
Molecular Weight:
490.73
Package Type:
Vial
Product Description:
Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species. Extensive pharmacological effects have been attributed to cycloastragenol, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties, improvement of lipid metabolism and wound repair promotion. It has been shown to inhibit endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and NLRP3 inflammasome-mediated pyroptosis. It improved immune function in CD8+ T lymphocytes from HIV-1-infected patients. It might be a novel candidate for age-associated diseases.
Purity:
>98% (HPLC)
SMILES:
O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O)[C@@]4([H])C(C)(C)[C@@H](O)CC[C@]45[C@]3(C5)CC[C@]2(C)[C@H]1[C@]6(C)O[C@H](C(C)(O)C)CC6
Solubility Chemicals:
Soluble in DMSO (10mg/ml), ethanol (3mg/ml) or DMF (10mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) S.R. Fauce, et al.; J. Immunol. 181, 7400 (2008) | (2) J. Zhu, et al.; Drug Metab. Pharmacokinet. 25, 477 (2010) | (3) F.C. Ip, et al.; Neurosignals 22, 52 (2014) | (4) S. Wang, et al.; BBRC 450, 306 (2014) | (5) Y. Zhao, et al.; J. Ethnopharmacol. 169, 210 (2015) | (6) Y. Wan, et al.; Eur. J. Pharmacol. 833, 545 (2018) | (7) Y. Yu, et al.; Exp. Ther. Med. 16, 2175 (2018) | (8) G. Deng, et al.; Int. Immunopharmacol. 74, 105682 (2019) | (9) Y. Cao, et al.; Biomed. Res. Int. 2019, 7023950 (2019)