Glabridin
| Code | Size | Price |
|---|
| CDX-G0194-M005 | 5 mg | £65.00 |
Quantity:
| CDX-G0194-M025 | 25 mg | £114.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
RT
Documents
Further Information
Alternate Names/Synonyms:
(R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl)-1,3-benzenediol
Appearance:
White to light brown powder.
CAS:
59870-68-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChiKey:
LBQIJVLKGVZRIW-ZDUSSCGKSA-N
Long Description:
Chemical. CAS: 59870-68-7. Formula: C20H20O4. MW: 324.37. Glabridin is a prenylated isoflavonoid found in licorice (Glycyrrhiza glabra L.) root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor and estrogen-like properties. These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors and act as a selective estrogen receptor modulator. On a molecular level it is, next to other targets, activating PPARgamma, inhibiting JNK1/2 and human carboxylesterase 2 (CES2A). Based on its antioxidant capacity it is also studied as an anti-aging cosmetic agent. Recently, it has been shown in docking experiments to have high binding affinity to the main protease of SARS-CoV-2.
MDL:
MFCD03427694
Molecular Formula:
C20H20O4
Molecular Weight:
324.37
Package Type:
Vial
Product Description:
Glabridin is a prenylated isoflavonoid found in licorice (Glycyrrhiza glabra L.) root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor and estrogen-like properties. These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors and act as a selective estrogen receptor modulator. On a molecular level it is, next to other targets, activating PPARgamma, inhibiting JNK1/2 and human carboxylesterase 2 (CES2A). Based on its antioxidant capacity it is also studied as an anti-aging cosmetic agent. Recently, it has been shown in docking experiments to have high binding affinity to the main protease of SARS-CoV-2.
Purity:
>98% (HPLC)
SMILES:
CC1(C)C=CC2=C(C=CC3=C2OC[C@@H](C4=C(O)C=C(O)C=C4)C3)O1
Solubility Chemicals:
Soluble in DMSO, ethanol or DMF (all 20mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) C. Simmler, et al.; Fitoterapia 90, 160 (2013) | (2) L. Wang, et al.; Acta. Pharmac. Sin. B 5, 310 (2015) | (3) K.J. Lee, et al.; Evid.-Based Compl. Altern. Med. 2015, ID 165457 (2015) | (4) J.F. Rebhun, et al.; Fitoterapia 106, 55 (2015) | (5) C.-T. Chen, et al.; Environ. Toxicol. 33, 679 (2018) | (6) Y.-Q. Song, et al.; Int. J. Biol. Macromol. 137, 261 (2019) | (7) P. Ciganovic, et al.; Antioxidants 8, 445 (2019) | (8) Z.-F. Wang, et al.; Curr. Med. Chem. 27, 1997 (2020) (Review) | (9) R. Islam, et al.; J. Biomol. Struct. Dyn. (Epub ahead of Print) (2020) | (10) B. Goel, et al.; Nat. Prod. Res. (Epub ahead of Print) (2020)