Pseudolaric acid B
| Code | Size | Price |
|---|
| CDX-P0453-M001 | 1 mg | £84.00 |
Quantity:
| CDX-P0453-M010 | 10 mg | £346.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
(-)-Pseudolaric acid B; Pseudolarix acid B; PLAB; PAB; NSC 615488
Appearance:
White to off-white powder.
CAS:
82508-31-4
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06,GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H301-H361
InChi:
InChI=1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22+,23-/m0/s1
InChiKey:
VDGOFNMYZYBUDT-YDRCMHEVSA-N
Long Description:
Chemical. CAS: 82508-31-4. Formula: C23H28O8. MW: 432.46. Pseudolaric acid B is a natural diterpenoid isolated from the bark of Pseudolarix kaempferi. It has anti-inflammatory, anticancer, immunosuppressive, antifungal and antifertility properties. Effects relevant to its anticancer properties include, apoptosis and autophagy induction, preventing angiogenesis, microtubule-destabilizing, induction of cell cycle arrest, inhibition of multidrug resistance and inhibition of tumor growth in vivo. It inhibits NF-kappa and p38 signaling and has been shown to be a PPARalpha signaling agonist.
MDL:
MFCD26960905
Molecular Formula:
C23H28O8
Molecular Weight:
432.46
Package Type:
Vial
PG:
III
Precautions:
P281-P301 + P310
Product Description:
Pseudolaric acid B is a natural diterpenoid isolated from the bark of Pseudolarix kaempferi. It has anti-inflammatory, anticancer, immunosuppressive, antifungal and antifertility properties. Effects relevant to its anticancer properties include, apoptosis and autophagy induction, preventing angiogenesis, microtubule-destabilizing, induction of cell cycle arrest, inhibition of multidrug resistance and inhibition of tumor growth in vivo. It inhibits NF-kappa and p38 signaling and has been shown to be a PPARalpha signaling agonist.
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
O=C(C)O[C@@]12[C@@]3(CC[C@@]2([H])[C@](C)(OC3=O)/C=C/C=C(C)/C(O)=O)CC=C(C(OC)=O)CC1
Solubility Chemicals:
Soluble in DMSO (10mg/ml) or ethanol (10mg/ml).
Source / Host:
Plant
Transportation:
Excepted Quantity
UN Nummer:
2811
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) B.N. Zhou, et al.; Planta Med. 47, 35 (1983) | (2) E. Li, et al.; J. Nat. Prod. 58, 57 (1995) | (3) M.S. Jardat, et al.; Planta Med. 68, 667 (2002) | (4) W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004) | (5) M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004) | (6) V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005) | (7) Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006) | (8) T. Li, et al.; J. Cell Biochem. 108, 87 (2009) | (9) G. Ma, et al.; J. Cancer Res. Clin. Oncol. 136, 1333 (2010) | (10) L. Hou, et al.; J. Cancer Res. Clin. Oncol. 138, 885 (2012) | (11) N. Wei, et al: Phytother. Res. 27, 980 (2013) | (12) J. Tong, et al.; Phytother. Res. 27, 885 (2013) | (13) Q. Sun & Y. Li; PLoS One 9, e107830 (2014) | (14) M.L. Liu, et al.; Front. Pharmacol. 8, 394 (2017) (Review)