Aloe-Emodine
| Code | Size | Price |
|---|
| CDX-A0658-M050 | 50 mg | £96.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; 3-Hydroxymethylchrysazine; Rhabarberone; Diacerein Impurity B; NSC 38628
Appearance:
Yellow to orange powder.
CAS:
481-72-1
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H335
InChi:
InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
InChiKey:
YDQWDHRMZQUTBA-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 481-72-1. Formula: C15H10O5. MW: 270.24. Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Aloe vera leaves and other plants. Aloe-emodin has been shown to exhibit many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. It has potent laxative action by activating CFTR Cl- channels and inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle. It also demonstrates anti-tumor activity, inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species (ROS) and induces apoptosis in glioma models through disruption of the mitochondria membrane potential. Aloe-emodin is reported to have estrogenic activity as a phytoestrogen, has been shown to inhibit breast cancer cell proliferation by downregulating ERalpha protein levels, and neuroprotective effects in vivo.
MDL:
MFCD00017373
Molecular Formula:
C15H10O5
Molecular Weight:
270.24
Package Type:
Vial
Precautions:
P261-P305 + P351 + P338
Product Description:
Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Aloe vera leaves and other plants. Aloe-emodin has been shown to exhibit many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. It has potent laxative action by activating CFTR Cl- channels and inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle. It also demonstrates anti-tumor activity, inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species (ROS) and induces apoptosis in glioma models through disruption of the mitochondria membrane potential. Aloe-emodin is reported to have estrogenic activity as a phytoestrogen, has been shown to inhibit breast cancer cell proliferation by downregulating ERalpha protein levels, and neuroprotective effects in vivo.
Purity:
>98% (HPLC)
Signal Word:
Warning
SMILES:
OC1=C2C(C(C(C=C(CO)C=C3O)=C3C2=O)=O)=CC=C1
Solubility Chemicals:
Soluble in DMSO (2mg/ml) or DMF (5mg/ml). Insoluble in water.
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) T. Pecere, et al.; Cancer Res. 60, 2800 (2000) | (2) H. Matsuda, et al.; Bioorg. Med. Chem. Lett. 11, 1839 (2001) | (3) G. Srinivas, et al.; Med. Res. Rev. 27, 591 (2007) (Review) | (4) H. Yang, et al.; Acta Pharmacol. Sin. 32, 834 (2011) | (5) K. Liu, et al.; Carcinogenesis 33, 1406 (2012) | (6) J. Xu, et al.; Br. J. Pharmacol. 165, 197 (2012) | (7) P.H. Huang, et al.; Evid. Based Compl. Alternat. Med. 2013, 1 (2013) | (8) S. Ismail, et al.; J. Asian Nat. Prod. Res. 15, 1003 (2013) | (9) M.J. Xie, et al.; Asian Pac. J. Cancer Prev. 15, 5201 (2014) | (10) L. Tao, et al.; Bioorg. Med. Chem. Lett. 24, 5385 (2014) | (11) R. Chen, et al.; Am. J. Chin. Med. 42, 275 (2014) (Review) | (12) X. Dong, et al.; Phytother. Res. [Epub ahead of print] (2019) (Review)