trans-Piceatannol
| Code | Size | Price |
|---|
| CDX-P0592-M005 | 5 mg | £78.00 |
Quantity:
| CDX-P0592-M025 | 25 mg | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
3,3',4,5'-Stilbenetetrol; 3,3',4,5'-Tetrahydroxy-trans-stilbene; Astringenin; CCRIS 9289; NSC365798; NSC622471; 3-Hydroxyresveratrol
Appearance:
Light tan to yellow powder.
CAS:
10083-24-6
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
InChiKey:
CDRPUGZCRXZLFL-OWOJBTEDSA-N
Long Description:
Chemical. CAS: 10083-24-6. Formula: C14H12O4. MW: 244.24. Piceatannol is a resveratrol analog with anticancer, anti-inflammatory, antioxidant, neuroprotective and cardioprotective properties. It is a spleen tyrosine kinase (Syk) inhibitor, however it exhibits antiproliferative activity by inhibiting a wide range of tyrosine and serine/threonine protein kinases, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. It suppresses NF-kappa activation through inhibition of IkappaBalpha kinase and NLRP3 activation. It is an apoptosis and autophagy inducer, cell cycle inhibitor, activator of SIRT1 and also inhibits adipogenesis.
MDL:
MFCD00221715
Molecular Formula:
C14H12O4
Molecular Weight:
244.24
Package Type:
Vial
Product Description:
Piceatannol is a resveratrol analog with anticancer, anti-inflammatory, antioxidant, neuroprotective and cardioprotective properties. It is a spleen tyrosine kinase (Syk) inhibitor, however it exhibits antiproliferative activity by inhibiting a wide range of tyrosine and serine/threonine protein kinases, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. It suppresses NF-kappa activation through inhibition of IkappaBalpha kinase and NLRP3 activation. It is an apoptosis and autophagy inducer, cell cycle inhibitor, activator of SIRT1 and also inhibits adipogenesis.
Purity:
>98% (HPLC)
SMILES:
OC1=CC(/C=C/C2=CC(O)=CC(O)=C2)=CC=C1O
Solubility Chemicals:
Soluble in DMSO (10 mg/mL) or ethanol (10 mg/mL).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) R.L. Geahlen, et al.; BBRC 165, 241 (1989) | (2) B.H. Wang, et al.; Planta Med. 64, 195 (1998) | (3) T. Wieder, et al.; Leukemia 15, 1735 (2001) | (4) F. Wolter, et al.; J. Nutr. 132, 298 (2002) | (5) K. Ashikawa, et al.; J. Immunol. 169, 6490 (2002) | (6) K.T. Howitz, et al.; Nature 425, 191 (2003) | (7) B.S. Wung, et al.; Pharmacol. Res. 53, 113 (2006) | (8) Z. Ovesna, et al.; Oncol. Rep. 16, 617 (2006) | (9) H.J. Kim, et al.; Ann. N Y Acad. Sci. 1095, 473 (2007) | (10) Y.H. Kim, et al.; Oncol. Rep. 19, 961 (2008) | (11) K.H. Choi, et al.; Cardiovasc. Res. 85, 836 (2010) | (12) H. Piotrowska, et al.; Mutat. Res. 750, 60 (2012) (Review) | (13) J.Y. Kwon, et al.; J. Biol. Chem. 287, 11566 (2012) | (14) Y. Kita, et al.; J. Biomed. Biotechnol. 2012, 672416 (2012) | (15) M. Minakawa, et al.; BBRC 422, 469 (2012) | 16) F. Pietrocola, et al.; Cell Cycle 11, 3851 (2012) | (17) Y.J. Surh & H.K. Na; Adv. Exp. Med. Biol. 928, 185 (2016) (Review) | (18) J. Kershaw & K.H. Kim; J. Med. Food 20, 427 (2017) (Review) | (19) J. Wen, et al.; Int. Immunopharmacol. 64, 131 (2018) | (20) K. Banik, et al.; Pharmacol. Res. 153, 104635 (2020) (Review)