Calycosin
| Code | Size | Price |
|---|
| CDX-C0642-M010 | 10 mg | £164.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
3',7-Dihydroxy-4'-methoxy-isoflavone; 3'-Hydroxyformononetin
Appearance:
White to light yellow powder.
CAS:
20575-57-9
Class:
6.1
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS06
Handling Advice:
Protect from light and moisture.
Hazards:
H301
InChi:
InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3
InChiKey:
QAGGICSUEVNSGH-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 20575-57-9. Formula: C16H12O5. MW: 284.26. Calycosin is an isoflavone and phytoestrogen with diverse biological properties, including anti-cancer, anti-inflammatory, antioxidant, neuroprotective, antiplasmodial and antiprotozoal activities. It is an estrogen receptor (ER) partial agonist that inhibits 17beta-estradiol binding to ERalpha and ER, promotion angiogenesis. It has been shown to have calcium blocking activities. Suppressed breast cancer cell growth via ER?-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Shown to induce apoptosis in several cancer types and having antimetastatic and anti-tumor activities.
MDL:
MFCD00210598
Molecular Formula:
C16H12O5
Molecular Weight:
284.26
Package Type:
Vial
PG:
III
Precautions:
P301 + P310
Product Description:
Calycosin is an isoflavone and phytoestrogen with diverse biological properties, including anti-cancer, anti-inflammatory, antioxidant, neuroprotective, antiplasmodial and antiprotozoal activities. It is an estrogen receptor (ER) partial agonist that inhibits 17beta-estradiol binding to ERalpha and ER, promotion angiogenesis. It has been shown to have calcium blocking activities. Suppressed breast cancer cell growth via ER?-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Shown to induce apoptosis in several cancer types and having antimetastatic and anti-tumor activities.
Purity:
>98% (HPLC)
Signal Word:
Danger
SMILES:
O=C1C=C(C2=CC=C(OC)C(O)=C2)OC3=CC(O)=CC=C31
Solubility Chemicals:
Soluble in DMSO (20mg/ml), DMF (20mg/ml) or methanol (1mg/ml).
Source / Host:
Plant
Transportation:
Excepted Quantity
UN Nummer:
3462
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) C. Kraft, et al.; J. Ethnopharmacol. 73, 131 (2000) | (2) D.-H. Yu, et al.; Biomed. Environ. Sci. 18, 297 (2005) | (3) X.L. Wu, et al.; Acta Pharmacol. Sin. 27, 1007 (2006) | (4) M.M. Salem & K.A. Werbovetz; J. Nat. Prod. 69, 43 (2006) | (5) J.Y. Tang, et al.; PLoS One 5, e11822 (2010) | (6) C. Guo, et al.; J. Ethnopharmacol. 144, 768 (2012) | (7) J. Chen, et al.; PLoS One 9, e91245 (2014) | (8) R. Qiu, et al.; Exp. Mol. Pathol. 97, 17 (2014) | (9) X. Zhao, et al.; Gene 591, 123 (2016) | (10) L. Song, et al.; Neural. Regen. Res. 12, 1870 (2017) | (11) L. Dong, et al.; Gene 675, 94 (2018) | (12) R. Qiu, et al.; Biofactors 45, 975 (2019) | (13) C. Huang, et al.; Med. Sci. Monit. 25, 5589 (2019)