Ellagic acid
| Code | Size | Price |
|---|
| CDX-E0232-G001 | 1 g | £78.00 |
Quantity:
| CDX-E0232-G005 | 5 g | £280.00 |
Quantity:
| CDX-E0232-G010 | 10 g | £407.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone; Alizarin Yellow; Benzoaric acid; Elagostasine; Gallogen; Lagistase; TBBD
Appearance:
Brown powder.
CAS:
476-66-4
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
InChiKey:
AFSDNFLWKVMVRB-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 476-66-4. Formula: C14H6O8. MW: 302.19. Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark and peels. It has antioxidant, anticancer, neuroprotective, antimutagenic, anti-inflammatory and organ-preserving properties. It alters cytochrome P450 activity and improvea metabolism and clearance of xenobiotics, as well as altera immune function. Selective, ATP-competitive inhibitor of casein kinase 2 (CK2). Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity. It acts as a scavenger of oxygen species produced by hydrogen peroxide treatment and as a protector of the DNA double helix from alkylating agent injury. Also reported to inhibit topoisomerases I and II and gyrase and glutathione S-transferase.
MDL:
MFCD00006914
Molecular Formula:
C14H6O8
Molecular Weight:
302.19
Package Type:
Vial
Product Description:
Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark and peels. It has antioxidant, anticancer, neuroprotective, antimutagenic, anti-inflammatory and organ-preserving properties. It alters cytochrome P450 activity and improvea metabolism and clearance of xenobiotics, as well as altera immune function. Selective, ATP-competitive inhibitor of casein kinase 2 (CK2). Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity. It acts as a scavenger of oxygen species produced by hydrogen peroxide treatment and as a protector of the DNA double helix from alkylating agent injury. Also reported to inhibit topoisomerases I and II and gyrase and glutathione S-transferase.
Purity:
>95% (HPLC)
SMILES:
OC1=CC2=C3C(OC(C4=C3C(OC2=O)=C(O)C(O)=C4)=O)=C1O
Solubility Chemicals:
Slightly soluble in ethanol or DMSO (<1mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) C.T. Allen, et al.; Immunopharmacol. Immunotoxicol. 25, 409 (2003) | (2) G. Cozza, et al.; J. Med. Chem. 49, 2363 (2006) | (3) D.H. Han, et al.; Anticancer Res. 26, 3601 (2006) | (4) R. Hayeshi, et al.; Food Chem. Toxicol. 45, 286 (2007) | (5) D. Heber; Cancer Lett. 269, 262 (2008) | (6) C. Bell & S. Hawthorne; J. Pharm. Pharmacol. 60, 139 (2008) (Review) | (7) B.R. Selvi, et al.; J. Biol. Chem. 285, 7143 (2010) | (8) J. Paluszczak, et al.; Toxicol. Lett. 192, 119 (2010) | (9) M.A. Lea, et al.; Anticancer Res. 30, 311 (2010) | (10) H.M. Zhang, et al.; Cancer Biol. Med. 11, 92 (2014) (Review) | (11) W.R. Garc?a-Nino & C. Zazueta; Pharmacol. Res. 97, 84 (2015) (Review) | (12) T. Ahmed, et al.; Curr. Pharm. Des. 22, 1350 (2016) (Review) | (13) G. Derosa, et al.; Adv. Exp. Med. Biol. 928, 4473 (Review) | (14) A. Zeb; Mol. Cell Biochem. 448, 27 (2018) (Review) | (15) C. Ceci, et al.; Nutrients 10, E1756 (2018) | (16) S. Alfei, et al.; Eur. J. Med. Chem. 183, 111724 (2019) (Review)