Aloin
| Code | Size | Price |
|---|
| CDX-A0527-M050 | 50 mg | £114.00 |
Quantity:
| CDX-A0527-M100 | 100 mg | £188.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
1,8-Dihydroxy-10-(beta-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone; Aloin A; Barbaloin A; NSC 407305
Appearance:
Yellow Powder.
CAS:
1415-73-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14+,17-,19+,20-,21+/m1/s1
InChiKey:
AFHJQYHRLPMKHU-OSYMLPPYSA-N
Long Description:
Chemical. CAS: 1415-73-2. Formula: C21H22O9. MW: 418.39. Isolated from plant source. Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Aloin is a chemopreventive and antineoplastic agent. It is a cytotoxic against cancer cells. As a anticancer agent it inhibits Topoisomerase II alpha, induces apoptosis, targets High Mobility Group Box 1 (HMGB1) and inhibits angiogenesis. It has been shown to be a potent skin depigmenting agent, enhancing melanogenesis. It has been described as a tyroniase inhibitor. It regulates transglutaminase activity. In addition Aloin is an anti-inflammatory agent, inhibiting the NF-kappaB pathway, antitrypanosomal, iron chelating and microbiota modulating compound.
MDL:
MFCD00151160
Molecular Formula:
C21H22O9
Molecular Weight:
418.39
Package Type:
Vial
Product Description:
Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Aloin is a chemopreventive and antineoplastic agent. It is a cytotoxic against cancer cells. As a anticancer agent it inhibits Topoisomerase II alpha, induces apoptosis, targets High Mobility Group Box 1 (HMGB1) and inhibits angiogenesis. It has been shown to be a potent skin depigmenting agent, enhancing melanogenesis. It has been described as a tyroniase inhibitor. It regulates transglutaminase activity. In addition Aloin is an anti-inflammatory agent, inhibiting the NF-kappaB pathway, antitrypanosomal, iron chelating and microbiota modulating compound.
Purity:
>98% (HPLC)
SMILES:
OC1=C2C([C@@]([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)([H])C(C=C(CO)C=C4O)=C4C2=O)=CC=C1
Solubility Chemicals:
Soluble in DMSO or methanol (both 50mg/ml).
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) C. Tan, et al.; Chin. Med. J. 115, 1859 (2002) | (2) A.Y. Esmat, et al.; Cancer Biol. Ther. 5, 97 (2006) | (3) A. Niciforovic, et al.; Cancer Biol. Ther. 6, 1200 (2007) | (4) E.J. Buenz; Toxicol. In Vitro 22, 422 (2008) | (5) A.H.A. Farooqi, et al.; J. Med. Aro. Plant. Sci. 31, 159 (2009) | (6) M.Y. Park, et al.; Biosci. Biotechnol. Biochem. 73, 828 (2009) | (7) S. Ravi, et al.; J. Exp. Sci. 2, 10 (2011) | (8) S. Hazrati, et al.; J. Med. Plants. Res. 6, 1834 (2012) | (9) S.A. Ali, et al.; Planta Med. 78, 767 (2012) | (10) Q. Pan, et al.; Cancer Cell Int. 13, 69 (2013) | (11) Y. Tewabe, et al.; BMC Vet. Res. 10, 61 (2014) | (12) A.Y. Esmat, et al.; Pharm. Biol. 53, 138 (2015) | (13) Y. Pengjam, et al.; Phytomedicine 23, 417 (2016) | (14) M.D. Boudreau, et al.; Toxicol. Sci. 158, 302 (2017) | (15) X. Luo, et al.; Molecules 23, E517 (2018) | (16) H. Tao, et al.; Drug Des. Devel. Ther. 13, 1221 (2019)