Apigenin

Chamomile; Flavone; NSC 83244; Versulin; 4',5,7-Trihydroxyflavone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone

Yellow to brown powder.

520-36-5

32160000

liquid

Protect from light and moisture.

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

KZNIFHPLKGYRTM-UHFFFAOYSA-N

Chemical. CAS: 520-36-5. Formula: C15H10O5. MW: 270.24. Isolated from plant source. Apigenin is an antioxidant plant flavonoid with anti-inflammatory, angiogenic, neuroprotective and anticancer properties. It may induce apoptosis and inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Also known to be a MAP kinase inhibitor and a selectively inhibitor of casein kinase 2 (CK2). It is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.

MFCD00006831

C15H10O5

270.24

Vial

Apigenin is an antioxidant plant flavonoid with anti-inflammatory, angiogenic, neuroprotective and anticancer properties. It may induce apoptosis and inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Also known to be a MAP kinase inhibitor and a selectively inhibitor of casein kinase 2 (CK2). It is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Shown to selectively inhibits chymotrypsin-like and trypsin-like proteasome catalytic activity.

>95% (HPLC)

OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1

Soluble in DMSO (10mg/ml) or DMF (20mg/ml).

Isolated from plant source.

Non-hazardous

Natural Products/Extracts

12352200

Stable for at least 2 years after receipt when stored at -20°C.