Osthole
| Code | Size | Price |
|---|
| CDX-O0097-M010 | 10 mg | £84.00 |
Quantity:
| CDX-O0097-M050 | 50 mg | £181.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
7-Methoxy-8-(3-methyl-2-butenyl)coumarin; 7-Methoxy-8-isopentenylcoumarin; NSC 31868
Appearance:
White to off-white powder.
CAS:
484-12-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
InChiKey:
MBRLOUHOWLUMFF-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 484-12-8. Formula: C15H16O3. MW: 244.29. Synthetic. Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-alpha, NF-kappaB, TGF-beta, cyclooxygenases, leukotrienes, nitric oxide, ERK and JNK. Shows also anti-cancer, chemopherapeutic, analgesic, neuroprotective, antipruritic, anti-leishmania and anti-lipedemic activities. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Selectively inhibits TRPV3 channels in skin. Induces apoptosis and cell cycle arrest in cancer cells. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.
MDL:
MFCD00076049
Molecular Formula:
C15H16O3
Molecular Weight:
244.29
Package Type:
Vial
Product Description:
Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-alpha, NF-kappaB, TGF-beta, cyclooxygenases, leukotrienes, nitric oxide, ERK and JNK. Shows also anti-cancer, chemopherapeutic, analgesic, neuroprotective, antipruritic, anti-leishmania and anti-lipedemic activities. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Selectively inhibits TRPV3 channels in skin. Induces apoptosis and cell cycle arrest in cancer cells. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.
Purity:
>95% (HPLC)
SMILES:
O=C1OC2=C(C/C=C(C)/C)C(OC)=CC=C2C=C1
Solubility Chemicals:
Soluble in DMSO, DMF, ethanol (all 20mg/ml) or methanol (10mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) R.L. Huang, et al.; Hepatology 24, 508 (1996) | (2) L. Wang, et al.; J. Biomed. Res. 29, 132 (2015) | (3) Z.R. Zhang, et al.; Evid.-Based Complem. Altern. Med. 2015, 919616 (2016) | (4) E.K. Kermani, et al.; Pharmacognosy Res. 8, S1 (2016) | (5) X.M. Xu, et al.; Oncol. Lett. 12, 3779 (2016) | (6) Y. Che, et al.; Oncol. Rep. 40, 737 (2018) | (7) X.Y. Sun, et al.; Mol. Pharmacol. 94, 1164 (2018) | (8) Y. Yao, et al.; Life Sci. 217, 16 (2019)