Olaparib
| Code | Size | Price |
|---|
| CDX-O0144-M100 | 100 mg | £108.00 |
Quantity:
| CDX-O0144-G001 | 1 g | £437.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
AZD 2281; Ku-0059436; Lynparza; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
Appearance:
Off-white to beige powder.
CAS:
763113-22-0
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H301-H360D-H372-H412
InChi:
InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChiKey:
FDLYAMZZIXQODN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 763113-22-0. Formula: C24H23FN4O3. MW: 434.47. Synthetic. Olaparib is a cell-permable potent inhibitor of PARP1 and PARP2 (IC50=5 and 1nM, respectively) but is less effective against the PARP tankyrase-1 (IC50=1.5µM). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in base excision repair (BER), counteracting against DNA alkylating agents. Olaparib is a anticancer and chemotherapeutic agent (especially in cancers with BRCA mutations) that can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.
MDL:
MFCD13185161
Molecular Formula:
C24H23FN4O3
Molecular Weight:
434.47
Package Type:
Vial
Product Description:
Olaparib is a cell-permable potent inhibitor of PARP1 and PARP2 (IC50=5 and 1nM, respectively) but is less effective against the PARP tankyrase-1 (IC50=1.5µM). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in base excision repair (BER), counteracting against DNA alkylating agents. Olaparib is a anticancer and chemotherapeutic agent (especially in cancers with BRCA mutations) that can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
O=C(C1CC1)N2CCN(C(C3=C(F)C=CC(CC(C4=C5C=CC=C4)=NNC5=O)=C3)=O)CC2
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or DMF (10mg/ml). Slightly soluble in ethanol (1mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) K.A. Menear, et al.; J. Med. Chem. 51, 6581 (2008) | (2) S. Rottenberg, et al.; PNAS 105, 17079 (2008) | (3) B.P. Rowe & P.M. Glazer; Breast Cancer Res. 12, 1 (2010) | (4) Y. Yuan, et al.; J. Hematol. Oncol. 4, 1 (2011) | (5) R. Plummer; Breast Cancer Res. 13, 1 (2011) | (6) M. Javle & N.J. Curtin; Ther. Adv. Med. Oncol. 3, 257 (2011) | (7) D. Davar, et al.; Curr. Med. Chem. 19, 3907 (2012) | (8) C.C. Gunderson & K.N. Moore; Future Oncol. 11, 747 (2015) | (9) F. De Felice, et al.; Drug Des. Devel. Ther. 11, 547 (2017) | (10) J. Stewart, et al.; Expert Rev. Anticancer Ther. 18, 947 (2018)