ARS-1630

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TargetMol
Product Code: TAR-T10376
Supplier: TargetMol
CodeSizePrice
TAR-T10376-1mg1mg£138.00
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TAR-T10376-5mg5mg£230.00
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TAR-T10376-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T10376-10mg10mg£303.00
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TAR-T10376-25mg25mg£530.00
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TAR-T10376-50mg50mg£731.00
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TAR-T10376-100mg100mg£938.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
ARS-1630 is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1. It is a less active enantiomer of ARS-1620.
CAS:
1698055-86-5
Formula:
C21H17ClF2N4O2
Molecular Weight:
430.84
Pathway:
GPCR/G Protein; MAPK
Purity:
0.9781
SMILES:
C=CC(N1CCN(C2=C3C=C(Cl)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[R]
Target:
Ras

References

1. Liansheng Li, et al. Inhibitors of kras g12c. WO 2015054572 A1. 2. Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172(3):578-589.e17.