CHMFL-EGFR-202

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TargetMol
Product Code: TAR-T10802
Supplier: TargetMol
CodeSizePrice
TAR-T10802-1mg1mg£227.00
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TAR-T10802-2mg2mg£306.00
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TAR-T10802-5mg5mg£430.00
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TAR-T10802-1mL1 mL * 10 mM (in DMSO)£503.00
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TAR-T10802-10mg10mg£600.00
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TAR-T10802-25mg25mg£863.00
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TAR-T10802-50mg50mg£1,179.00
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TAR-T10802-100mg100mg£1,589.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).
CAS:
2089381-40-6
Formula:
C25H24ClN7O2
Molecular Weight:
489.96
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis
Purity:
0.9919
SMILES:
NC1=C2C(=NN(C2=NC=N1)[C@H]3CN(C(C=C)=O)CCC3)C4=CC(Cl)=C(OCC5=CC=CC=N5)C=C4
Target:
EGFR

References

1. Wang A, et al. Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.