McMMAF

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TargetMol
Product Code: TAR-T16031
Supplier: TargetMol
CodeSizePrice
TAR-T16031-1mg1mg£111.00
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TAR-T16031-5mg5mg£168.00
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TAR-T16031-10mg10mg£229.00
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Quantity:
TAR-T16031-25mg25mg£436.00
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Quantity:
TAR-T16031-50mg50mg£610.00
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Quantity:
TAR-T16031-100mg100mg£838.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.
CAS:
863971-19-1
Formula:
C49H76N6O11
Molecular Weight:
925.178
Pathway:
Cytoskeletal Signaling
Purity:
1
SMILES:
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C
Target:
Microtubule Associated

References

1. Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69(6):2358-2364. 2. Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.