7-Hydroxymethotrexate
| Code | Size | Price |
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| TAR-T20339-1mg | 1mg | £349.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
7-Hydroxymethotrexate is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. 2 Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models.
CAS:
5939-37-7
Formula:
C20H22N8O6
Molecular Weight:
470.446
Purity:
0.98
SMILES:
CN(Cc1nc2c(N)nc(N)[nH]c2nc1=O)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
References
1. Silva MF, Ribeiro C, Gon?alves VMF, Tiritan ME, Lima ?. Liquid chromatographic methods for the therapeutic drug monitoring of methotrexate as clinical decision support for personalized medicine: A brief review. Biomed Chromatogr. 2018 May;32(5):e4159. doi: 10.1002/bmc.4159. Epub 2018 Jan 12. Review. PubMed PMID: 29226354.
2. Fabresse N, Devictor B, Pissier C, Chambost H, Lacarelle B, Michel G, Solas C. Plasma 7-Hydroxymethotrexate Levels Versus Methotrexate to Predict Delayed Elimination in Children Receiving High-Dose Methotrexate. Ther Drug Monit. 2018 Feb;40(1):76-83. doi: 10.1097/FTD.0000000000000445. PubMed PMID: 29120974.
3. Bia?k-Bieli?ska A, Mulkiewicz E, Stokowski M, Stolte S, Stepnowski P. Acute aquatic toxicity assessment of six anti-cancer drugs and one metabolite using biotest battery - Biological effects and stability under test conditions. Chemosphere. 2017 Dec;189:689-698. doi: 10.1016/j.chemosphere.2017.08.174. Epub 2017 Sep 21. PubMed PMID: 28968575.
4. Patel H, Giri P, Ghoghari A, Delvadia P, Syed M, Srinivas NR. Review of the bioanalytical methods for the determination of methotrexate and its metabolites in in vitro, preclinical and clinical studies: Case studies and perspectives. Biomed Chromatogr. 2017 Jan;31(1). doi: 10.1002/bmc.3849. Epub 2016 Oct 17. Review. PubMed PMID: 27623319.