Gypsogenin
Code | Size | Price |
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TAR-T25476-1mg | 1mg | £180.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25476-5mg | 5mg | £337.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25476-1mL | 1 mL * 10 mM (in DMSO) | £366.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25476-10mg | 10mg | £466.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25476-25mg | 25mg | £703.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25476-50mg | 50mg | £970.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25476-100mg | 100mg | £1,267.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Gypsogenin is a naturally occurring biochemical that shows anti-ABL1 kinase and anti-chronic Myelogenous Leukemia activities.
CAS:
639-14-5
Formula:
C30H46O4
Molecular Weight:
470.694
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; Cytoskeletal Signaling
Purity:
0.9861
SMILES:
[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)[C@@](C)(C=O)[C@]3([H])CC[C@@]12C)C(O)=O
Target:
Bcr-Abl
References
1. Heller L , Schwarz S , Weber B A , et al. Gypsogenin Derivatives: An Unexpected Class of Inhibitors of Cholinesterases[J]. Archiv Der Pharmazie, 2015, 347(10):707-716.
2. Ciftci HI, Ozturk SE, Ali TFS, Radwan MO, Tateishi H, Koga R, Ocak Z, Can M, Otsuka M, Fujita M. The First Pentacyclic Triterpenoid Gypsogenin Derivative Exhibiting Anti-ABL1 Kinase and Anti-chronic Myelogenous Leukemia Activities. Biol Pharm Bull. 2018 Apr 1;41(4):570-574. doi: 10.1248/bpb.b17-00902. Epub 2018 Jan 30. PubMed PMID: 29386476.
3. Qu YF, Gao JY, Wang J, Geng YM, Zhou Y, Sun CX, Li F, Feng L, Yu MJ, Wang GS. New Triterpenoid Saponins from the Herb Hylomecon japonica. Molecules. 2017 Oct 23;22(10). pii: E1731. doi: 10.3390/molecules22101731. PubMed PMID: 29065554.
4. Smu?ek W, Zdarta A, Pacholak A, Zgo?a-Grze?kowiak A, Marczak ?, Jarz?bski M, Kaczorek E. Saponaria officinalis L. extract: Surface active properties and impact on environmental bacterial strains. Colloids Surf B Biointerfaces. 2017 Feb 1;150:209-215. doi: 10.1016/j.colsurfb.2016.11.035. Epub 2016 Nov 27. PubMed PMID: 27918965.