Sordarin sodium
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| TAR-T36434-1mg | 1mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T36434-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).[1] [2] It inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml).
CAS:
463356-00-5
Formula:
C27H39O8.Na
Molecular Weight:
514.6
Purity:
0.98
SMILES:
C[C@H]1O[C@@H](OC[C@@]23[C@@](C(C(C)C)=C[C@@]3([H])C4)(C([O-])=O)[C@@]4(C=O)[C@@]5([H])[C@]([C@H](C)CC5)([H])C2)[C@@H](O)[C@H](O)[C@@H]1OC.[Na+]
References
Dom?nguez, J.M., G?mez-Lorenzo, M.G., and Mart?n, J.J. Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. J. Biol. Chem. 274(32), 22423-22427 (1999).
Dom?nguez, J.M., Kelly, V.A., Kinsman, O.S., et al. Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts. Antimicrob. Agents Chemother. 42(9), 2274-2278 (1998).