Bottromycin A2
| Code | Size | Price |
|---|
| TAR-T36706-1mg | 1mg | £1,042.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) and vancomycin-resistantEnterococciwith MIC values of 1 and 0.5 μg/ml, respectively.
CAS:
15005-62-6
Formula:
C42H62N8O7S
Molecular Weight:
823.1
Purity:
0.98
SMILES:
O=C1[C@@]2([H])N(CC[C@H]2C)C(C/N=C([C@@H](NC([C@@H](N1)C(C)C)=O)C(C)(C)C)/N[C@@H](C(C)(C)C)C(N[C@H](C(N[C@@H](C3=NC=CS3)CC(OC)=O)=O)[C@H](C4=CC=CC=C4)C)=O)=O
References
Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967)
Gouda, H., Kobayashi, Y., Yamada, T., et al.Three-dimensional solution structure of bottromycin A2: A potent antibiotic active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant EnterococciChem. Pharm. Bull. (Tokyo)60(2)169-171(2012)