Ras Inhibitory Peptide

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TargetMol
Product Code: TAR-T37422
Supplier: TargetMol
CodeSizePrice
TAR-T37422-1mg1mg£185.00
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Quantity:
TAR-T37422-5mg5mg£586.00
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Quantity:
TAR-T37422-10mg10mg£966.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.
CAS:
159088-48-9
Formula:
C53H91N19O11
Molecular Weight:
1170.4
Purity:
0.98
SMILES:
[H]N[C@@H](C(C)C)C(N1CCC[C@H]1C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@@H](C(C)C)C(N4CCC[C@H]4C(N5CCC[C@H]5C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O