S-methyl-KE-298
Code | Size | Price |
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TAR-T4282-1mg | 1mg | £345.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4282-5mg | 5mg | £688.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4282-1mL | 1 mL * 10 mM (in DMSO) | £698.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4282-10mg | 10mg | £978.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4282-25mg | 25mg | £1,420.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4282-50mg | 50mg | £1,910.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4282-100mg | 100mg | £2,456.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from ?rheumatoid arthritis (RA) synovial cells.
CAS:
143584-75-2
Formula:
C13H16O3S
Molecular Weight:
252.33
Pathway:
Metabolism; Proteases/Proteasome
Purity:
0.969
SMILES:
CSCC(CC(=O)c1ccc(C)cc1)C(O)=O
Target:
MMP; Drug Metabolite
References
Honda S, et al. Expression of membrane-type 1 matrix metalloproteinase in rheumatoid synovial cells. Clin Exp Immunol. 2001 Oct;126(1):131-6.
Yoshida H , Kohno Y , Endo H , et al. Identification of metabolites of KE-298, a new antirheumatic drug, and its physiological properties in rats.[J]. Biological & Pharmaceutical Bulletin, 1996, 19(3):424-9.
Yoshida H , Kohno Y , Endo H , et al. Stereoselective disposition and chiral inversion of KE-298, a new antirheumatic drug, in rats[J]. Chirality, 2015, 9(1):22-28.