Protostemonine
| Code | Size | Price |
|---|
| TAR-T4S0083-10mg | 10mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
1. Protostemonine has anti-inflammatory activity, it effectively attenuates LPS-induced inflammatory responses in vitro and in vivo; the beneficial effects are associated with the decreased phosphorylation of MAPK and AKT and the reduced expression of pro-inflammatory mediators, such as iNOS, NO and cytokines. 2. Protostemonine shows strong nematicidal activity against Panagrellus redivevus, with the IC50 value of 0.10 uM. 3. Protostemonine attenuates LPS/GalN-induced acute liver failure and upregulating HO-1 expression is implicated in its hepatoprotective activity. 4. Protostemonine shows significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration.
CAS:
27495-40-5
Formula:
C23H31NO6
Molecular Weight:
417.502
Purity:
0.98
SMILES:
COC1=C(C)C(=O)OC1=C1/O[C@@H]2CCCN3[C@@H](CC[C@H]3[C@H]2[C@@H]1C)[C@@H]1C[C@H](C)C(=O)O1
References
Wu Y X , He H Q , Nie Y J , et al. Protostemonine effectively attenuates lipopolysaccharide-induced acute lung injury in mice[J]. Acta Pharmacologica Sinica, 2017.