Atractylenolide II
| Code | Size | Price |
|---|
| TAR-T5S0168-1mL | 1 mL * 10 mM (in DMSO) | £135.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T5S0168-20mg | 20mg | £183.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.
CAS:
73069-14-4
Formula:
C15H20O2
Molecular Weight:
232.323
Pathway:
Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; MAPK; Stem Cells; Apoptosis; JAK/STAT signaling
Purity:
0.9989
SMILES:
CC1=C2C[C@H]3C(=C)CCC[C@]3(C)C[C@@H]2OC1=O
Target:
Apoptosis; ERK; p38 MAPK; Akt; STAT
References
Wang F, Li Z, Chen L, et al. Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1?/NF-?B feedback pathway to inhibit liver fibrosis. Acta Pharmaceutica Sinica B. 2022
Fu X Q , Chou G X , Kwan H Y , et al. Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II[J]. Experimental Dermatology, 2014, 23(11):855-857.
Cao L, Xu E, Zheng R, et al. Traditional Chinese medicine Lingguizhugan decoction ameliorate HFD-induced hepatic-lipid deposition in mice by inhibiting STING-mediated inflammation in macrophages. Chinese Medicine. 2022, 17(1): 1-16.