Desmethyl Erlotinib hydrochloride
Code | Size | Price |
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TAR-T6619-1mg | 1mg | £114.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T6619-2mg | 2mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T6619-5mg | 5mg | £164.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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TAR-T6619-1mL | 1 mL * 10 mM (in DMSO) | £174.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T6619-10mg | 10mg | £230.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T6619-25mg | 25mg | £354.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6619-50mg | 50mg | £498.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6619-100mg | 100mg | £679.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
CAS:
183320-51-6
Formula:
C21H22ClN3O4
Molecular Weight:
415.87
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Metabolism
Purity:
0.9903
SMILES:
Cl.COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCO
Target:
EGFR; Drug Metabolite
References
Ali S, et al. Mol Cancer Ther, 2008, 7(6), 1708-1719.
Moyer JD, et al. Cancer Res. 1997, 57(21), 4838-4848.
Meany HJ, et al. Cancer Chemother Pharmacol. 2008, 62(3), 387-392.
Li T, et al. Clin Cancer Res, 2007, 13(11), 3413-3422.
Buck E, et al. Mol Cancer Ther. 2006, 5(11), 2676-2784.