Rosmanol
Code | Size | Price |
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TAR-T7033-1mg | 1mg | £125.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7033-5mg | 5mg | £189.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7033-1mL | 1 mL * 10 mM (in DMSO) | £201.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7033-10mg | 10mg | £254.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7033-25mg | 25mg | £454.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7033-50mg | 50mg | £623.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7033-100mg | 100mg | £839.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
CAS:
80225-53-2
Formula:
C20H26O5
Molecular Weight:
346.423
Pathway:
oxidation-reduction; Neuroscience; Immunology/Inflammation
Purity:
0.9882
SMILES:
CC(C)c1cc2[C@H](O)[C@H]3OC(=O)[C@@]4(CCCC(C)(C)[C@H]34)c2c(O)c1O
Target:
Antioxidant; COX
References
Fischedick J T. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the antioxidant response element[J]. Bioorganic & Medicinal Chemistry, 2013, 21(9):2618-2622.
Li T, Lu D, Yao C, et al. Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. Nature Communications. 2022, 13(1): 1-16.
Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis [J]. J Pharm Pharm Sci. 2015;18(4):448-59.
Petiwala S M, Johnson J J. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity[J]. Cancer Letters, 2015, 367(2):93-102.