Dot1L-IN-4

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TargetMol
Product Code: TAR-T8881
Supplier: TargetMol
CodeSizePrice
TAR-T8881-1mg1mg£227.00
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TAR-T8881-2mg2mg£294.00
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TAR-T8881-5mg5mg£402.00
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TAR-T8881-1mL1 mL * 10 mM (in DMSO)£544.00
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TAR-T8881-10mg10mg£567.00
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TAR-T8881-25mg25mg£862.00
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TAR-T8881-50mg50mg£1,139.00
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TAR-T8881-100mg100mg£1,508.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.
CAS:
2565705-02-2
Formula:
C28H27ClF2N8O5S
Molecular Weight:
661.08
Pathway:
Chromatin/Epigenetic
Purity:
0.9956
SMILES:
COc1nc(Nc2cc(ccc2N[C@H](c2cccc3OC(F)(F)Oc23)c2ncccc2Cl)S(C)(=O)=O)nc(n1)N1CCNCC1
Target:
Histone Methyltransferase

References

Stauffer F, Weiss A, Scheufler C, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med Chem Lett. 2019;10(12):1655-1660. Published 2019 Dec 4. doi:10.1021/acsmedchemlett.9b00452